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The Expected Blood-Group Antibody, anti-Lub


The Lutheran blood group system was first described by Callender and Race1 in 1946: an antibody, afterwards named anti-Lua, was found to react with the red cells of approximately 8 per cent of the English population. The antigen with which the antibody reacts is called Lua and can be recognized in the red cells of heterozygous as well as homozygous individuals. The corresponding gene is called Lua and an allele Lub is postulated. The antigen Lub has been recognizable so far only as an absence of Lua; thus persons of the phenotype Lu(a–) are presumed to be of the genotype Lua Lub.

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  1. 1

    Callender, Sheila T., and Race, R. R., Ann. Eugen., 13, 102 (1946).

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  2. 2

    Race, R. R., and Sanger, Ruth, “Blood Groups in Man”, 2nd edit. (Blackwell Scientific Publications, Oxford, 1954).

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CUTBUSH, M., CHANARIN, I. The Expected Blood-Group Antibody, anti-Lub. Nature 178, 855–856 (1956).

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