Abstract
THE experiments described here were undertaken to ascertain the pattern of purine utilization and turnover in the nucleic acids of different types of leukæmic leucocytes. The results indicate that leukæmic lymphocytes survive longer than leukæmic granulocytes. The results also direct attention to the possibility of re-utilization of large fragments of nucleic acids by lymphocytes, and invite speculation on the significance of this process as an explanation of the problem in long-term immunity of how formation of antibody continues long after the limited contact between tissues and antigen.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Shemin, D., and Rittenberg, D., J. Biol. Chem., 166, 627 (1946).
Heiberg, K. A., Acta Med. Scand., 65 443 (1926–27). Bloom, W., “Handbook of Hematology”, edit. Downey, 2, 1429 (Hoeber, New York, 1938). Maximow, cited by Bloom, ibid., 1488.
Chase, M. W., Proc. Soc. Exp. Biol. and Med., 59, 134 (1945). Mitchison, N. A., Nature, 171, 267 (1953).
Billingham, R. E., Brent, L., and Medawar, P. B., Nature, 172, 603 (1953).
Heidelberger, M., Treffen, H. P., Schoenheimer, R., Ratner, S., and Rittenberg, D., J. Biol. Chem., 144, 555 (1942). Bulman, N., and Campbell, D. H., Proc. Soc. Exp. Biol. and Med., 84, 155 (1953).
Hamilton, L. D., Henry Ford Hospital Symposium, “The Leukemias: Etiology and Pathophysiology” (Academic Press, New York, in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HAMILTON, L. Nucleic Acid Turnover Studies in Human Leukæmic Cells and the Function of Lymphocytes. Nature 178, 597–599 (1956). https://doi.org/10.1038/178597a0
Issue Date:
DOI: https://doi.org/10.1038/178597a0
This article is cited by
-
Lymphocytenabbau nach in-vitro-Markierung mit Na 2 51 CrO4
Klinische Wochenschrift (1967)
-
DNS- und RNS-Synthese in benignen und malignen Lymphomen
Klinische Wochenschrift (1967)
-
Lymphocyte Foot Appendage: Its Role in Lymphocyte Function and in Immunological Reactions
Nature (1965)
-
Abbau der Lymphocyten Tuberkulosekranker im defibrinierten Venenblut
Beiträge zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung (1964)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.