Abstract
IN a communication on lysergic acid diethylamide, Axelrod, Brady, Witkop and Evarts1 state: “Although the hallucinogenic agent, lysergic acid diethylamide, has been the subject of numerous investigations, little is known about its biological fate”. However, a number of facts, not mentioned in this communication, about the destruction, distribution and excretion of this compound have recently been published which show that we are not quite as ignorant about the biological fate of this compound as one might infer from this statement.
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References
Axelrod, J., Brady, R. O., Witkop, B., and Evarts, E. V., Nature, 178, 143 (1956).
Lanz, U., Cerletti, A., and Rothlin, E., Helv. Physiol. Acta, 13, 207 (1955).
Boyd, E. S., Rothlin, E., Bonner, J. F., Slater, J. H., and Hodge, H. C., J. Pharmacol., 113, 6 (1955).
Stoll, A., Rothlin, E., Rutschmann, J., and Schalch, W. A., Experientia, 11, 396 (1955).
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ROTHLIN, E. Metabolism of Lysergic Acid Diethylamide. Nature 178, 1400–1401 (1956). https://doi.org/10.1038/1781400a0
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DOI: https://doi.org/10.1038/1781400a0
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