Occurrence of ‘Lumps’ of Coagulated Material in the Bladders of Adrenalectomized Guinea Pigs

Abstract

DURING the past five years, seventy-six male guinea pigs from four different colonies have successfully undergone bilateral adrenalectomy. Of these, twenty-two have afterwards developed ‘lumps’ in their bladders. These animals appeared healthy until a few hours before death. The ‘lumps’, composed of a firm yellow cheese-like material and weighing 9–800 mgm., were circular with a diameter varying from approximately 0.25 to 1.0 cm. and they had frequently a small projection which might block the urethra. The bladder did not always contain urine, and the ureters were never dilated.