Abstract
GRAFTS derived from ovarian tissue which has been treated with glycerol and frozen to, and stored at, − 79° C. are endocrinologically active but contain comparatively few oocytes1. The oocytes which survive freezing and thawing can mature and undergo ovulation even in subcutaneous grafts2; but it is not yet known whether they are capable of normal fertilization and development. An approach to this problem involves orthotopic grafting at the ovarian site of the ovariectomized or sterilized recipient and, ideally, the use of a graft from a genetically distinguishable donor so that the source of any offspring produced is not in doubt. With the animals at present available at this Institute the latter requirement implies interstrain ovarian homografting and has led us to consider possible methods of attenuating or suspending the immunological reaction evoked by such grafts.
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PARKES, A. Attenuation of Host Reaction to Ovarian Homografts. Nature 178, 1228 (1956). https://doi.org/10.1038/1781228a0
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DOI: https://doi.org/10.1038/1781228a0
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