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Zymogen Formation in the Mouse Pancreas

Abstract

THERE are present in the Golgi zone of each acinar cell of the mammalian pancreas a number of small lipoidal droplets (about 1½µ in diameter) which stain with methylene blue and other vital dyes. Each lipochondrion, or, where vesiculated, its cortex, is intensely osmiophilic and concentrates vital dyes1. Hirsch2, and later Baker3 and Lacy4, considered that the prozymogen granules arose within the vacuolated lipochondria and when mature (1½µ in diameter) were released into the apical part of the cell.

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References

  1. Xeros, N., Nature, 167, 448 (1951).

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  2. Hirsch, H. C., “Form und Stoffwechsel der Golgi-Korper”. Protoplasma Monographs (Borntraeger, Berlin, 1939).

  3. Baker, J. R., Quart. J. Micro. Sci., 90, 293 (1949).

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  4. Lacy, D., Nature, 175, 302 (1955).

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  5. Worley, L. G., J. Morph., 261, 75 (1944).

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XEROS, N. Zymogen Formation in the Mouse Pancreas. Nature 177, 843–844 (1956). https://doi.org/10.1038/177843a0

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  • DOI: https://doi.org/10.1038/177843a0

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