Abstract
GANGLIOSIDES are lipids closely allied to the cerebrosides. They were so named because of their occurrence mainly in the ganglion cells of the nervous system, although gangliosides seem to exist in most parenchymatous organs. Klenk et al.
1, for example, have isolated gangliosides from brain, spleen and red cells. The composition of ganglioside from brain as given by Klenk had to be modified after the isolation of chondrosamine from brain ganglioside by us2, and in a recent paper Klenk et al. suggested its composition as follows :
In the same paper they also assert the existence of only one type of ganglioside from brain.
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References
Klenk, E., Z. physiol. Chem., 273, 76 (1942). Klenk, E., and Rennkamp, F., ibid., 273, 253 (1942). Klenk, E., and Lauenstein, K., ibid., 295, 164 (1953).
Blix, G., Svennerholm, L., and Werner, I., Acta Chem. Scand., 6, 358 (1952).
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Yamakawa, T., Suzuki, S., and Hattori, T., J. Biochem. (Tokyo), 40, 611 (1953).
Svennerholm, L., Acta Chem. Scand., 8, 1108 (1954).
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Folch, J., Asrove, A., and Meath, J. A., J. Biol. Chem., 191, 819 (1951).
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SVENNERHOLM, L. Composition of Gangliosides from Human Brain. Nature 177, 524–525 (1956). https://doi.org/10.1038/177524b0
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DOI: https://doi.org/10.1038/177524b0
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