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An Erythrocyte Sphering Factor in Rat and Mouse Plasma

Abstract

WHEN suspensions of many types of mammalian red cells in saline media are examined between a glass slide and coverslip, the cells change their shape from biconcave disks, through a stage of crenation, to spheres1. This change is associated with the removal or inactivation of an anti-sphering factor normally present in plasma albumin2.

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References

  1. Hamburger, H. J., Pflüger's Arch., 141, 230 (1895).

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  2. Furchgott, R. F., and Ponder, E., J. Exp. Biol., 17, 117 (1940); Ponder, E., “Hemolysis and Related Phenomena” (Churchill, London, 1948).

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  3. Trotter, W. D., D.Phil. Thesis, Oxford (1954); Brit. J. Haematol. (in the press).

  4. Robinson, D. S., Jeffries, G. H., and French, J. E., J. Exp. Physiol., 39, 165 (1954).

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BARER, R., GAFFNEY, F. An Erythrocyte Sphering Factor in Rat and Mouse Plasma. Nature 177, 277–278 (1956). https://doi.org/10.1038/177277a0

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