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Anticoagulant Specificity and Physiologically Inactive Beta-Prothromboplastin


A SMALL number of hæmophilic patients at first benefit by blood or plasma transfusions but later develop in their blood an anticoagulant which renders further transfusions temporarily ineffective. It is believed that the anticoagulant is an antibody due to the transfused antigen1, but positive precipitin tests have been obtained infrequently.

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FANTL, P., SAWERS, R. Anticoagulant Specificity and Physiologically Inactive Beta-Prothromboplastin. Nature 177, 1233–1234 (1956).

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