A SMALL number of hæmophilic patients at first benefit by blood or plasma transfusions but later develop in their blood an anticoagulant which renders further transfusions temporarily ineffective. It is believed that the anticoagulant is an antibody due to the transfused antigen1, but positive precipitin tests have been obtained infrequently.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Craddock, C. S., and Lawrence, J. S., Blood, 2, 505 (1947).
Aggeler, P. M., White, S. G., Glendening, M. B., Page, E. P., Leake, T. B., and Bates, G., Proc. Soc. Exp. Biol. Med., 79, 162 (1952).
Biggs, R., Douglas, A. S., MacFarlane, R. G., Dacie, J. V., Pitney, W. R., Merskey, C., and O'Brien, J. R., Brit. Med. J., ii, 1378 (1952).
Bell, W. N., and Alton, H. G., Nature, 174, 880 (1954).
Fantl, P., Aust. J. Exp. Biol. Med. Sci., 32, 853 (1954).
Frommeyer, W. B., Epstein, R. D., and Taylor, F. H. L., Blood, 5, 401 (1950).
Rights and permissions
About this article
Cite this article
FANTL, P., SAWERS, R. Anticoagulant Specificity and Physiologically Inactive Beta-Prothromboplastin. Nature 177, 1233–1234 (1956). https://doi.org/10.1038/1771233a0
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.