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Theory of Antibiotic Inhibition Zones in Agar Media

Nature volume 176, pages 510–511 (1955)Cite this article

Abstract

SINCE Cooper and Woodman1 proposed on theoretical grounds that the formula should explain the size of inhibition zones, under specified experimental conditions, evidence on the validity of this proposal has been accumulated by many workers. The variables in the formula have been further analysed, and it is now possible to give an extended explanation of their meaning, which should give a more accurate understanding of the factors influencing the size of inhibition zones.

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References

  1. Cooper, K. E., and Woodman, D., J. Path. and Bact., 58, 75 (1946).

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  2. Cooper, K. E., and Linton, A. H., J. Gen. Microbiol., 7, 8 (1952).

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  3. Mitchison, D. A., and Spicer, C. G., J. Gen. Microbiol., 3, 184 (1949).

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  4. Cooper, K. E., and Gillespie, W. A., J. Gen. Microbiol., 7, 1 (1952).

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  5. Linton, A. H. (personal communication, 1955), and Proc. Soc. Gen. Microbiol. (April 1955).

  6. Linton, A. H., “Studies in the Viability of Bacterial Populations”, Ph.D. thesis, Bristol (1954).

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Authors and Affiliations

  1. Department of Preventive Medicine, University of Bristol,

    K. E. COOPER

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  1. K. E. COOPER
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COOPER, K. Theory of Antibiotic Inhibition Zones in Agar Media. Nature 176, 510–511 (1955). https://doi.org/10.1038/176510b0

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