Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Characterization and Genetics of Hæmoglobin G

Nature volume 175, pages 850–851 (1955)Cite this article

Abstract

IN the course of a survey of Gold Coast Africans1, one individual was discovered who had both normal hæmoglobin and one hitherto not known which was designated as hæmoglobin G 2. Hæmoglobin G was found to differ from all other known hæmoglobins in its mobility on paper electrophoresis at pH 8.6 (veronal buffer). The hæmoglobins most similar in mobility were sickle-cell hæmoglobin (S), fœtal hæmoglobin (F) and hæmoglobin D. S could in addition be differentiated by its low solubility when in the reduced state, and F by its resistance towards denaturation by alkali. For the distinction from hæmoglobin D, reliance had to be placed on the reported mobility of the latter, which was exactly that of S in open-boundary electrophoresis at acid and at alkaline pH3. Further steps have now been taken to establish the properties of hæmoglobin G.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Edington, G. M., and Lehmann, H., Trans. Roy Soc. Trop. Med. Hyg., 48, 332 (1954).

    Article  CAS  Google Scholar 

  2. Edington, G. M., and Lehmann, H., Lancet, ii, 173 (1954).

  3. Itano, H. A., Proc. U.S. Nat. Acad. Sci., 37, 775 (1951).

    Article  ADS  CAS  Google Scholar 

  4. Cooke, J. V., and Mack, J. K., J. Pediat., 5, 601 (1934).

    Article  Google Scholar 

  5. Bergren, W. R., Sturgeon, P., and Itano, H. A., Acta Haematol., 12, 160 (1954).

    Article  CAS  Google Scholar 

  6. Itano, H. A., Arch. Biochem., 47, 148 (1953).

    Article  CAS  Google Scholar 

  7. Smith, E. W., and Conley, C. L., Bull. Johns Bopkins Hosp., 93, 94 (1953).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Institute, Accra, Gold Coast

    G. M. EDINGTON

  2. St. Bartholomew's Hospital, London, E.C.1.

    H. LEHMANN

  3. School of Medicine, University of Texas, Galveston, Texas

    ROSE G. SCHNEIDER

Authors
  1. G. M. EDINGTON
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. LEHMANN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. ROSE G. SCHNEIDER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

EDINGTON, G., LEHMANN, H. & SCHNEIDER, R. Characterization and Genetics of Hæmoglobin G . Nature 175, 850–851 (1955). https://doi.org/10.1038/175850a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/175850a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing