Letter | Published:

Biochemical Variations in Inbred Mice

Naturevolume 175pages11321133 (1955) | Download Citation



ATTENTION has been directed to skeletal variations within inbred mice strains by Grüneberg1 and by McLaren and Michie2. The latter workers have surveyed most of the available substrains of C 3 H mice and have found that they fall into two general categories having either five or six lumbar vertebræ. In the course of studies on the response of liver β-glucuronidase to hormone injections, it has now been found that there are two quite distinct levels of this enzyme in certain C 3 H substrains, and that this difference represents a genetical variation in the C 3 H strain.

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  1. 1

    Grüneberg, H., Nature, 173, 675 (1954).

  2. 2

    McLaren, A., and Michie, D., J. Embry. Exp. Morph., 2, 149 (1954).

  3. 3

    Fishman, W. H., and Farmelant, M. H., Endocrin., 52, 536 (1953).

  4. 4

    Law, L. W., Morrow, A. G., and Greenspan, E. M., J. Nat. Cancer Inst., 12, 900 (1952).

  5. 5

    Talalay, P., Fishman, W. H., and Huggins, C., J. Biol. Chem., 166, 757 (1946).

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  1. Cancer Research Laboratories, Medical School, Birmingham, 15

    • D. HAMER


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