Letter | Published:

Destruction of Isoniazid in the Presence of Hæmin

Naturevolume 175pages10851086 (1955) | Download Citation



IT has been shown that hæmin strongly antagonizes the antibacterial action of isoniazid (isonicotinoyl-hydrazine) on strains of Mycobacterium tuberculosis sensitive to this drug1. These observations have been confirmed and extended2. Isoniazid is destroyed in uninoculated media when hæmin is present (see ref. 3, also personal communication from G. P. Youmans). The work to be described was undertaken to find whether the destructive reaction was catalytic or not, to identify the products, and to consider some biological implications.

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  1. 1

    Fisher, M. W., Amer. Rev. Tubercul., 69, 469 and 797 (1954).

  2. 2

    Knox, R., J. Gen. Microbiol., 12, 191 (1955).

  3. 3

    Cohn, M. L., Oda, U., Kovitz, C., and Middlebrook, G., Amer. Rev. Tubercul., 70, 465 (1954).

  4. 4

    Krüger-Thiemer, E., Naturwiss., 42, 47 (1955).

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    Bönicke, R., and Reif, W., Naturwiss., 40, 606 (1953).

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    Barron, E. G., Cold Spring Harbor Symp. Quant. Biol., 7, “Biological Oxidations” (1939).

  7. 7

    Fisher, M. W., Amer. Rev. Tubercul., 66, 626 (1952).

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    Fisher, M. W., Proc. Soc. Exp. Biol. Med., 85, 538 (1954).

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  1. Department of Bacteriology, Guy's Hospital Medical School, London, S.E.1

  2. Department of Medical Chemistry, Australian National University, 183 Euston Road, London, N.W.1

    •  & C. W. REES


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