Abstract
GRAMICIDIN S is a polypeptide antibiotic elaborated by a strain of Bacillus brevis
1. Its postulated structure, well substantiated by experimental results2, is that of a cyclic decapeptide of the following nature3: 
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References
Gause, G. F., and Brazhnikova, M. G., Lancet, ii, 715 (1944).
Consden, R., Gordon, A., Martin, A. J. P., and Synge, R. L. M., Biochem. J., 41, 596 (1947). Battersby, A. R., and Craig, L. C., J. Amer. Chem. Soc., 73, 1887 (1951). Sanger, F., Biochem. J., 40, 261 (1946). Hodgkin, D. C., Cold Spring Harbor Symposia, 14, 65 (1949).
Abbreviations are discussed in ref. 6. In general, the first three letters are used to designate the amino-acid residue, for example, Leu = leucyl residue.
Harris, J. I., and Work, T. S., Biochem. J., 46, 196, 582 (1950).
Bricas, E., and Fromageot, C., “Adv. Prot. Chem.”, 8, 1 (1953).
Erlanger, B. F., Sachs, H., and Brand, E., J. Amer. Chem. Soc., 76, 1806 (1954).
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ERLANGER, B., GOODE, L. Gramicidin S: Relationship of Cyclic Structure to Antibiotic Activity. Nature 174, 840–841 (1954). https://doi.org/10.1038/174840a0
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DOI: https://doi.org/10.1038/174840a0
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