Abstract
RECENT interest in the rodent vaginal epithelium as a target organ for studying the interaction of dietary and endocrine factors1 has led to an investigation of the post-fœtal vaginal epithelium of the rat in tissue culture. Whereas Emmens and Ludford2 were unsuccessful in a similar attempt, quite recently Hardy, Biggers and Claringbold3 were able to culture the mouse vaginal epithelium by the hanging-drop method and demonstrated the sensitivity of this tissue to œstrogenic substances.
Similar content being viewed by others
Article PDF
References
Kahn, R. H., and Bern, H. A., Science, 111, 516 (1950); Amer. J. Anat. (in the press).
Emmens, C. W., and Ludford, R. J., Nature, 145, 746 (1940).
Hardy, M. H., Biggers, J. D., and Claringbold, P. J., Nature, 172, 1196 (1953).
Fell, H. B., and Robison, R., Biochem. J., 23, 767 (1929).
Fell, H. B., and Mellanby, E., J. Physiol., 119, 470 (1953).
Szego, C. M., and Roberts, S., “Recent Progress in Hormone Research”, 8, 419 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KAHN, R. Effect of Œstrogen and of Vitamin A on Vaginal Cornification in Tissue Culture. Nature 174, 317 (1954). https://doi.org/10.1038/174317a0
Issue Date:
DOI: https://doi.org/10.1038/174317a0
This article is cited by
-
Keratinization of rat vaginal epithelium IV. Modulation of transglutaminase activity by oestradiol
Journal of Biosciences (1988)
-
Autoradiographic analysis of hormone-independent development of the mouse vaginal epithelium in organ culture
In Vitro (1974)
-
The Cultivation of Embryonic Chicken Skin in a Chemically Defined Medium, and the Response of the Epidermis to Excess of Vitamin A**From the Strangeways Research Laboratory, Cambridge, England.
Journal of Investigative Dermatology (1967)
-
Ultrastructure of spontaneous vaginal keratinization in hanging-drop organ culture (Balb/cCrgl MICE)
Zeitschrift f�r Zellforschung und Mikroskopische Anatomie (1967)
-
Stratum Corneum Formation in Auto-Implants and in Explants of Human Skin*
Journal of Investigative Dermatology (1961)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.