Abstract
MANY theories have been put forward concerning the mechanism of protein synthesis, and most of them have suggested that ribonucleic acid acts as a template upon, or alongside which, peptide chains are synthesized. The arrangement of the amino-acids in the peptide chain is supposedly regulated by the highly specific arrangement of the nucleotides which, it has been suggested1,2, may contain high-energy phosphate at the proper intervals to effect peptide bond synthesis. A recent detailed account of this theory and some evidence for the phosphorylation of ribonucleic acid has been offered by Dounce1,3.
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References
Dounce, A. L., Enzymologia, 15, 251 (1952).
Pollister, A. W., “Chemistry and Physiology of the Nucleus”, 159 (Academic Press, N.Y., 1952).
Dounce, A. L., and Kay, E. R. M., Proc. Soc. Exp. Biol. Med., 83, 321 (1953).
Eichel, H. J., and Roth, J. S., Biol. Bull., 104, 351 (1953).
Eichel, H. J., J. Biol. Chem., 206, 159 (1954).
Lundblad, G., and Hultin, E., Exp. Cell. Res., 6, 249 (1954).
Roth, J. S., J. Biol. Chem., [208, 181 (1954)].
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ROTH, J. A Possible Function of Intracellular Ribonucleases. Nature 174, 129 (1954). https://doi.org/10.1038/174129a0
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DOI: https://doi.org/10.1038/174129a0
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