Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Enzymatic Conversion of Salicylhydroxamic Acid to Salicylamide

Abstract

AFTER the administration of Salicylhydroxamic acid to rats, we have been able to isolate conjugates of Salicylhydroxamic acid and salicylamide from the urine1. In the intact animal, Salicylhydroxamic acid is therefore partly metabolized to salicylamide. In the present communication, the enzymatic transformation of Salicylhydroxamic acid to salicylamide in vitro is reported.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Lowenthal, J. (unpublished results).

  2. Bray, H. G., James, S. P., Ryman, B. E., and Thorpe, W. V., Biochem. J., 42, 274 (1948).

    Article  CAS  Google Scholar 

  3. Virtanen, A. I., and Berg, A. M., Acta Chem. Scand., 5, 909 (1951).

    Article  CAS  Google Scholar 

  4. Waelsch, H., “Advances in Enzymology”, 13, 237 (1952).

    Google Scholar 

  5. Bueding, E., and Joliffe, N., J. Pharmacol. Exp. Therap., 88, 300 (1945).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

LOWENTHAL, J. Enzymatic Conversion of Salicylhydroxamic Acid to Salicylamide. Nature 174, 36–37 (1954). https://doi.org/10.1038/174036a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/174036a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing