Abstract
ACCORDING to Bacq and Herve1,2, cysteinamine (2-mercaptoethylamine) and methylamine protect mice against a lethal dose of X-irradiation. The amines prevent death, but do not inhibit X-ray damage to the testes. It was tempting, therefore, to see whether they reduce the toxicity of a ‘radiomimetic’ drug3 without at the same time reducing its specific activity. Colter and Quastel4 have already shown that, in vitro, methylamine protects choline oxidase against nitrogen mustard.
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References
Bacq, Z. M., and Herve, A., J. Physiol., 117, P8 (1952).
Bacq, Z. M., and Herve, A., Bull. Acad. méd. Belg., 17, 13 (1952).
Boyland, E., Endeavour, 11, 87 (1952).
Colter, J. S., and Quastel, J. H., Nature, 166, 773 (1950).
Peczenik, O., Brit. J. Cancer, 6, 262 (1952).
Ellinger, F., Proc. Soc. Exp. Biol., 80, 214 (1952).
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PECZENIK, O. Influence of Cysteinamine, Methylamine and Cortisone on the Toxicity and Activity of Nitrogen Mustard. Nature 172, 454–455 (1953). https://doi.org/10.1038/172454a0
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DOI: https://doi.org/10.1038/172454a0
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