Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Isotope Curves in Red Blood Cell Studies

Nature volume 171, pages 797–798 (1953)Cite this article

Abstract

WHEN iron-55 or a carbon-14—or nitrogen-15—labelled substrate is fed to an individual, a portion of the isotope is incorporated in red cell hæmoglobin1–4. Curves of subsequent changes in the amount of isotopic excess can be explained and used for calculating the survival curve of red cells, as well as their average time of utilizing the incorporated substance.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Shemin, D., and Rittenberg, D., J. Biol. Chem., 166, 627 (1946).

    CAS  PubMed  Google Scholar 

  2. Finch, C. A., Wolff, J. A., Rath, C. E., and Fluharty, R. G., J. Lab. and Clin. Med., 34, 1480 (1949).

    CAS  Google Scholar 

  3. Bale, W. F., Yuile, C. L., De La Vergne, L., Miller, L. L., and Whipple, G. H., J. Exp. Med., 90, 315 (1949).

    Article  CAS  Google Scholar 

  4. Hagen, P. S., Bull. Univ. Minn. Hosp., 23, 552 (1952).

    Google Scholar 

  5. Mollison, P. L., “Blood Transfusion in Clinical Medicine” (C. C. Thomas, Springfield, Ill., 1951).

    Google Scholar 

  6. Rimington, C., Acta Med. Scand., 143, 161 (1952).

    CAS  PubMed  Google Scholar 

  7. London, I. M., Shemin, D., West, R., and Rittenberg, L., J. Biol. Chem., 179, 463 (1949).

    CAS  PubMed  Google Scholar 

  8. Evans, R. L., Amatuzio, D. S., and Ebert, R. V., Science, 115, 572 (1952).

    Article  ADS  CAS  Google Scholar 

  9. Callender, S. T., Powell, E. O., and Witts, L. J., J. Path. Bact., 57, 129 (1945).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Veterans Administration Hospital, and the Department of Medicine, University of Minnesota, Minneapolis, Minn

    D. S. AMATUZIO

  2. Department of Mathematics and Mechanics, University of Minnesota, Minneapolis, Minn

    ROBERT L. EVANS

Authors
  1. D. S. AMATUZIO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. ROBERT L. EVANS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

AMATUZIO, D., EVANS, R. Isotope Curves in Red Blood Cell Studies. Nature 171, 797–798 (1953). https://doi.org/10.1038/171797b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/171797b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing