Abstract
KRECH1 has found that mice infected with tetanus spores could be saved by toxoid alone, an antitoxin not being used, whereas the control animals died. He also gave toxoid in two doses 24 and 48 hr. before a lethal dose of toxin. The eight mice injected with toxoid survived while the two control animals died on the sixth and ninth day respectively. He concluded that these effects were due to the rapid formation of antibodies. Lemétayer2, also using toxoid, was able to produce a retardation of the onset of the signs of tetanus if he gave it one day before the toxin.
Similar content being viewed by others
Article PDF
References
Krech, U., Z. Immun., 106, 241 (1949).
Lemétayer, E., Nicol, L., Girard, O., Corvazier, R., and Cheyroux, M., Ann. Inst. Pasteur, 79, 672 (1950).
Raynaud, M., Lemétayer, E., Turpin, A., Nicol, L., and Rouyer, M., C.R. Acad. Sci., Paris, 233, 586 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RAYNAUD, M., WRIGHT, E. Rapid Specific Preventive Action of Tetanus Toxoid. Nature 171, 797 (1953). https://doi.org/10.1038/171797a0
Issue Date:
DOI: https://doi.org/10.1038/171797a0
This article is cited by
-
Competition between tetanus toxoid and toxin
Bulletin of Experimental Biology and Medicine (1975)
-
Specific Precocious Protective Action of Toxoids
Nature (1964)
-
Über die Bindung von Tetanustoxin an Hirnsubstanz ohne und nach Vorbehandlung mit Tetanustoxoid
Zeitschrift für Hygiene und Infektionskrankheiten (1954)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.