Nature of Cold Agglutinin Linkage


IF sera containing auto-agglutinins (‘non-specific cold agglutinins’) are repeatedly absorbed in the cold with O cells, one of three results may be obtained: (1) activity against A and B cells may cease; this is the only result reported by numerous earlier workers; (2) activity against A and B cells may persist to a greater or lesser extent; subsequent absorption with A cells may leave some residual anti-B activity1; (3) activity against A and B cells may be enhanced2.


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BIRD, G. Nature of Cold Agglutinin Linkage. Nature 171, 748 (1953).

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