Abstract
IT was observed that when bacterial suspensions in broth were exposed to streptomycin in a concentration of 100 µgm. per ml. the survivors multiplied slowly after a prolonged lag phase1. It was also observed that, when bacterial suspensions containing 320–1,600 millions of Brucellæ per 10 ml. were exposed to streptomycin, then the resistant mutants appeared in them more frequently than in those containing 1,600–8,000 millions of Brucellæ in the same volume1.
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References
Olitzki, A. L., J. Gen. Microbiol., 6, 166 (1952).
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OLITZKI, A. A Growth-Inhibitor for Streptomycin-resistant Mutants in Dense Suspensions of Brucella abortus (Strain 19). Nature 171, 132–133 (1953). https://doi.org/10.1038/171132a0
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DOI: https://doi.org/10.1038/171132a0
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