Abstract
THE hypothesis advanced earlier to account for the toxicity of fluoroacetate (FCH2.COONa) has been proved recently by the isolation of an enzymically synthesized mono-fluorotricarboxylic acid in crystalline form1, prepared from the products of interaction of kidney tissue with fumarate and fluoroacetate. Though there was much to suggest that it was mono-fluorocitric acid, this had not been rigorously proved by a comparison of the infra-red spectrum with a synthetic specimen. The recent synthesis by one of us (D. E. A. R., in the press) of fluorocitric acid has made it possible to compare the infra-red spectra of the barium salts of this with the barium salt from 1.5 mgm. of the enzymically synthesized (natural) crystalline compound isolated in Oxford (by R. A. P. and R. W. W.).
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References
Peters, R. A., Wakelin, R. W., Buffa, P., and Thomas, L. C., Proc. Roy. Soc., B, 140, 497 (1953).
Peters, R. A., Brit. Med. J., ii, 1165 (1952). Peters, R. A., and Wakelin, R. W., J. Physiol. (in the press).
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PETERS, R., WAKELIN, R., RIVETT, D. et al. Fluoroacetate Poisoning: Comparison of Synthetic Fluorocitric Acid with the enzymically synthesized Fluorotricarboxylic Acid. Nature 171, 1111–1112 (1953). https://doi.org/10.1038/1711111a0
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DOI: https://doi.org/10.1038/1711111a0
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