Abstract
THE barbituric acid derivatives have a characteristic absorption spectrum in the ultra-violet, and this is the basis of the most reliable methods for their quantitative determination. Small changes of the wave-length at which maximal absorption is found and changes in the absorption curve with varying pH usually are considered to be the means by which the different members of the group can be identified. But these methods have been found troublesome and unreliable. However, as the strength of absorption differs quite appreciably from one member to another, the identification of the derivative is necessary for a quantitative determination.
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GRIEG, A. Paper Chromatographic Separation of Barbituric Acids. Nature 170, 845 (1952). https://doi.org/10.1038/170845a0
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DOI: https://doi.org/10.1038/170845a0
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