Abstract
IN a previous paper1, describing the beginning of a series of investigations on the action of D-amino-acids on L-peptidasic activity, it was observed that the effect of D(+)-leucine on hydrolysis of glycil-L-leucine by raw extracts of bovine intestinal mucosa clearly differed according to the pH of the reaction and to the final concentration of the D-amino-acid. D(+)-Leucine inhibited hydrolysis of glycil-L-leucine at a pH near the neutral point; it had no influence at an alkaline pH (8.5), while at an acid pH (6.2) it activated the reaction slightly.
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Vescia, A., Albano, A., and Iacono, A., Boll. Soc. Ital. Biol. Sper., 26, 99 (1950).
Vescia, A., Arch. Int. Physiol., 57, 46 (1949).
Grassmann, W., and Heyde, W., Z. phys. Chem., 183, 32 (1929).
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VESCIA, A., ALBANO, A. & IACONO, A. Effect of D(+)-Leucine on the Hydrolysis of Glycil-L-Leucine in Normal and Neoplastic Tissues. Nature 170, 804 (1952). https://doi.org/10.1038/170804a0
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DOI: https://doi.org/10.1038/170804a0
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