Abstract
IN 1948 Kenneford, Lourie, Morley, Simpson, Williamson and Wright1 reported that the crude reduction products of the cinnolinium salts (I; R = H or Me) showed considerable activity in infections of Trypanosoma congolense in mice, whereas the pure diamino-salts were inactive. They attributed this phenomenon to the probable presence in the crude products of azo-compounds (II; X = —N=N—) of high trypanocidal activity. It has recently2 been further demonstrated that structures of the general formula (II), where X may have values other than —N=N—, have trypanocidal properties, the most effective being ‘528’ (II; R = H, X = 
). 
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kenneford, J. R., Lourie, E. M., Morley, J. S., Simpson, J. C. E., Williamson, J., and Wright, P. H., Nature, 161, 603 (1948).
Lourie, E. M., Simpson, J. C. E., and Walker, J. M., Brit. J. Pharmacol., 6, 643 (1951).
Walls, L. P., J. Chem. Soc., 299 (1945).
Caldwell, A. G., and Walls, L. P., J. Chem. Soc., 193 (1948).
Walls, L. P., and Whittaker, N., J. Chem. Soc., 43 (1950).
Brownlee, G., Goss, M. D., Goodwin, L. G., Woodbine, M., and Walls, L. P., Brit. J. Pharmacol., 5, 261 (1950).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WALLS, L., BEVERIDGE, E. Reduction of Nitrophenanthridinium Salts: Influence of Molecular Size on Trypanocidal Activity. Nature 170, 666–667 (1952). https://doi.org/10.1038/170666a0
Issue Date:
DOI: https://doi.org/10.1038/170666a0
This article is cited by
-
Synthesis and structure of nitro-substituted 6(5H)-phenanthridinones
Chemistry of Heterocyclic Compounds (1985)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
