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Successful outcome of a disseminated adenovirus infection 6 years after allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 41, pages 411–412 (2008)Cite this article

Disseminated adenovirus (AV) disease is associated with mortality rates of 6–60% among allogeneic stem cell transplant recipients.1, 2, 3 Risk factors for AV infections in these patients include an unrelated or a T-cell depleted allogeneic transplant, alemtuzumab or irradiation in conditioning regimens, donor seropositive for AV, the presence of GVHD, concurrent immunosuppressive therapy.2, 4, 5, 6, 7 Adenoviral infections usually occur during the first 3 months following stem cell transplantation, at a time when immunosuppression is maximal.2, 7 Treatment with cidofovir is not always active in disseminated AV infections.8, 9

We report a case of disseminated AV infection developing more than 6 years after allogeneic hematopoietic stem cell transplantation.

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Authors and Affiliations

  1. Department of Infectious Diseases, Hopital Saint Louis, Assistance Publique-Hôpitaux de Paris and University of Paris, Paris, France

    L Willems, M Lagrange-Xélot, S Gallien & J M Molina

  2. Department of Bone Marrow Transplantation, Hopital Saint Louis, Assistance Publique-Hôpitaux de Paris and University of Paris, Paris, France

    M Robin & G Socié

  3. Microbiology Laboratory, Hopital Saint Louis, Assistance Publique-Hôpitaux de Paris and University of Paris, Paris, France

    C Scieux

Authors
  1. L Willems
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  2. M Lagrange-Xélot
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  4. M Robin
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  5. C Scieux
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  6. G Socié
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  7. J M Molina
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Correspondence to M Lagrange-Xélot.

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Willems, L., Lagrange-Xélot, M., Gallien, S. et al. Successful outcome of a disseminated adenovirus infection 6 years after allogeneic bone marrow transplantation. Bone Marrow Transplant 41, 411–412 (2008). https://doi.org/10.1038/sj.bmt.1705928

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