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Post-Transplant Events

High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia

Bone Marrow Transplantation volume 40, pages 773–778 (2007)Cite this article

Abstract

Secondary failure of platelet recovery (SFPR), which is a delayed decline in platelet count after primary recovery following myeloablative hematopoietic SCT, is a significant problem in allogeneic SCT. However, its clinical characteristics have not been well described in autologous SCT for acute myeloid leukemia. We reviewed 11 consecutive patients who had received autologous or syngeneic SCT for acute promyelocytic leukemia. Seven of 11 patients (64%) had SFPR, which is defined as a decline in the platelet count to less than 30 000/μl for more than 7 days. The median onset of SFPR was day 36 (range, 25–51 days) and the median duration of thrombocytopenia was 13 days (range, 4–25 days). Of nine patients who received busulfan-containing preparative regimens, seven (78%) had SFPR and one had delayed primary platelet count recovery. Neither patient who received cyclophosphamide and total body irradiation as preparative regimens had SFPR. The clinical courses of SFPR were transient and self-limited. SFPR was not associated with relapse of underlying diseases, graft failure or other fatal morbidities. The unexpectedly high prevalence and the characteristics of SFPR may provide additional information on management following autologous SCT for acute myeloid leukemia.

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Authors and Affiliations

  1. Department of Hematology and Oncology, JA Aichi Showa Hospital, Konan, Japan

    H Narimatsu, A Kohno, S Saito, K Shimada & Y Morishita

  2. Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    H Narimatsu, N Emi, M Yanada, T Yokozawa, T Naoe & K Yamamoto

  3. Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan

    M Iwai & H Kiyoi

  4. Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan

    K Yamamoto

  5. Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan

    K Yamamoto

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  1. H Narimatsu
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  2. N Emi
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  12. Y Morishita
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Correspondence to H Narimatsu.

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Narimatsu, H., Emi, N., Kohno, A. et al. High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia. Bone Marrow Transplant 40, 773–778 (2007). https://doi.org/10.1038/sj.bmt.1705820

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