Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Pediatric Transplants

Long-term outcomes after allogeneic stem cell transplantation for children with hematological malignancies

Bone Marrow Transplantation volume 40, pages 219–224 (2007)Cite this article

Abstract

We analyzed long-term outcomes and psycho-social aspects in 112 children with malignancies surviving 1 year after hematopoietic stem cell transplantation. At 10 years, overall survival was 75±5%, TRM 18±4% and relapse 14±3%; 10-year cumulative incidence of infections was 31±4%, cataract 44±4%, pulmonary dysfunction 20±4%, bone and joint complications 29±5%, hypothyroidism 36±4%, cardiac complications 11±3% and secondary malignancies 7±3%. Total body irradiation (TBI) was the most significant risk factor associated with cataract, pulmonary impairment, osteoarticular complications and hypothyroidism. Chronic graft-versus-host disease was associated with higher incidence of pulmonary dysfunction. The number of complications per patient increased with time. Half of the patients had psychological disturbance, 13 signs of depression and 16 a history of eating behavior disorders; 54% of patients with one or more long-term complications had psychological problems. Sixty-nine patients had learning difficulties and 36 achieved normal scholarship. With increased follow-up, development of late effects and of psycho-social disturbance are of major concern. While the use of single-dose TBI has now been abandoned, other risk factors are still of concern in the early 2000s.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. Socie G, Salooja N, Cohen A, Rovelli A, Carreras E, Locasciulli A et al. Nonmalignant late effects after allogeneic stem cell transplantation. Blood 2003; 101: 3373–3385.

    Article  CAS  Google Scholar 

  2. Deeg HJ, Socie G, Schoch G, Henry-Amar M, Witherspoon RP, Devergie A et al. Malignancies after marrow transplantation for aplastic anemia and fanconi anemia: a joint Seattle and Paris analysis of results in 700 patients. Blood 1996; 87: 386–392.

    CAS  PubMed  Google Scholar 

  3. Curtis RE, Rowlings PA, Deeg HJ, Shriner DA, Socie G, Travis LB et al. Solid cancers after bone marrow transplantation. N Engl J Med 1997; 336: 897–904.

    Article  CAS  Google Scholar 

  4. Socie G, Curtis RE, Deeg HJ, Sobocinski KA, Filipovich AH, Travis LB et al. New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia. J Clin Oncol 2000; 18: 348–357.

    Article  CAS  Google Scholar 

  5. Deeg HJ, Leisenring W, Storb R, Nims J, Flowers ME, Witherspoon RP et al. Long-term outcome after marrow transplantation for severe aplastic anemia. Blood 1998; 91: 3637–3645.

    CAS  PubMed  Google Scholar 

  6. Sakaida E, Nakaseko C, Harima A, Yokota A, Cho R, Saito Y et al. Late-onset noninfectious pulmonary complications after allogeneic stem cell transplantation are significantly associated with chronic graft-versus-host disease and with the graft-versus-leukemia effect. Blood 2003; 102: 4236–4242.

    Article  CAS  Google Scholar 

  7. Faraci M, Calevo MG, Lanino E, Caruso S, Messina C, Favr C et al. Osteonecrosis after allogeneic stem cell transplantation in childhood. A case–control study in Italy. Haematologica 2006; 91: 1096–1099.

    PubMed  Google Scholar 

  8. Ochs L, Shu XO, Miller J, Enright H, Wagner J, Filipovich A et al. Late infections after allogeneic bone marrow transplantations: comparison of incidence in related and unrelated donor transplant recipients. Blood 1995; 86: 3979–3986.

    CAS  Google Scholar 

  9. Barrera M, Boyd-Pringle LA, Sumbler K, Saunders F . Quality of life and behavioral adjustment after pediatric bone marrow transplantation. Bone Marrow Transplant 2000; 26: 427–435.

    Article  CAS  Google Scholar 

  10. Andrykowski MA, Carpenter JS, Greiner CB, Altmaier EM, Burish TG, Antin JH et al. Energy level and sleep quality following bone marrow transplantation. Bone Marrow Transplant 1997; 20: 669–679.

    Article  CAS  Google Scholar 

  11. Leung W, Hudson MM, Strickland DK, Phipps S, Srivastava DK, Ribeiro RC et al. Late effects of treatment in survivors of childhood acute myeloid leukemia. J Clin Oncol 2000; 18: 3273–3279.

    Article  CAS  Google Scholar 

  12. Thompson JR, Gustafson KE . Adaptation to Chronic Childhood Illness. American Psychological Association: Washington, DC, 1996.

    Book  Google Scholar 

  13. Baker F, Zabora J, Polland A, Wingard J . Reintegration after bone marrow transplantation. Cancer Pract 1999; 7: 190–197.

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. C Ferry and G Gemayel: These authors contributed equally to this study and should thus be considered both as first author.

Authors and Affiliations

  1. Hematopoietic Stem Cell Transplant, Hôpital Saint Louis, Paris, France

    C Ferry, G Gemayel, V Rocha, H Esperou, M Robin, R P de Latour, P Ribaud, A Devergie, E Gluckman & G Socié

  2. Acute Leukemia Working Party of European Blood and Marrow Transplant Group, Hopital Saint Antoine, Paris, France

    M Labopin

  3. Pediatric Hematology, Hospital Saint Louis, Paris, France

    T Leblanc & A Baruchel

Authors
  1. C Ferry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G Gemayel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V Rocha
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M Labopin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H Esperou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M Robin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R P de Latour
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P Ribaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Devergie
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. T Leblanc
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. E Gluckman
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. A Baruchel
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. G Socié
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G Socié.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ferry, C., Gemayel, G., Rocha, V. et al. Long-term outcomes after allogeneic stem cell transplantation for children with hematological malignancies. Bone Marrow Transplant 40, 219–224 (2007). https://doi.org/10.1038/sj.bmt.1705710

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1705710

Keywords

This article is cited by

Search

Advanced search

Quick links