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Successful matched unrelated BMT for secondary AML which developed simultaneously with relapsed Hodgkin's lymphoma

Bone Marrow Transplantation volume 39, pages 569–570 (2007)Cite this article

Although most patients with Hodgkin's lymphoma (HL) can be cured with first-line therapy, long-term survivors are at risk for secondary malignancy as well as for relapse of the primary disease. Myelodysplasia (MDS) and acute mycloid leukemia (AML) are the most frequently observed secondary malignancies, and outcomes are poor.1 Management for relapsed HL also remains a challenge. To date, there have been no case reports of relapsed HL with a concurrent secondary malignancy. Here, we report a patient with relapsed HL who simultaneously developed secondary AML, was successfully treated with a matched unrelated BMT, and who then became disease-free.

A 29-year-old Japanese woman with widespread cervical lymphadenopathy was diagnosed with HL (mixed cellularity, CS IIB) in August 1999. She underwent six courses of standard ABVD chemotherapy, and achieved complete remission (CR) after receiving an additional 40 Gy irradiation to the remaining cervical lesions in March 2001. She remained in CR for 3 years, but developed generalized lymphadenopathy in June 2004. Biopsy revealed a relapse of the primary HL. She also presented with pancytopenia and a small amount of blastic cells in her peripheral blood. Her BM specimen was hypercellular with a 70% increase in myeloperoxidase-positive myeloblasts and no evidence of HL cells. The blasts were positive for CD13, CD33, CD34 and HLA-DR. A chromosome analysis revealed complex abnormalities including a partial deletion of chromosome 11q, thus indicating relapsed HL and secondary AML (M2).

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Acknowledgements

We thank Ms Megumi Naito for her technical assistance in chimerism analysis and Ms Kimie Shibuya for her secretarial assistance.

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Authors and Affiliations

  1. Department of Clinical Cell Biology, Division of Hematology, Chiba University Graduate School of Medicine, Chiba, Japan

    C Ohwada, C Nakaseko, H Tanaka, D Abe, K Oda, S Ozawa, M Takeuchi, N Shimizu, R Cho, Y Saito & M Nishimura

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  1. C Ohwada
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  2. C Nakaseko
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  3. H Tanaka
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  4. D Abe
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  6. S Ozawa
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  7. M Takeuchi
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  8. N Shimizu
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  10. Y Saito
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  11. M Nishimura
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Correspondence to C Ohwada.

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Ohwada, C., Nakaseko, C., Tanaka, H. et al. Successful matched unrelated BMT for secondary AML which developed simultaneously with relapsed Hodgkin's lymphoma. Bone Marrow Transplant 39, 569–570 (2007). https://doi.org/10.1038/sj.bmt.1705642

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