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Hepatosplenic αβ T-cell lymphoma successfully treated with allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 39, pages 513–514 (2007)Cite this article

Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of peripheral T-cell lymphoma characterized in young adult males by hepatosplenomegaly, B-symptoms, peripheral blood cytopenias and no lymphadenopathy; lymphomatous infiltrates in the splenic red pulp, hepatic sinusoids and bone marrow sinuses; T cell receptor (TCR) γδ-chain and cytotoxic T-cell phenotype; isochromosome (i) 7q in conjunction with other abnormalities, most commonly trisomy 8; and aggressive clinical course.1, 2, 3, 4

Recently, rarer types of HSTCL with αβ T-cell phenotype (HSαβTCL) have occasionally been reported.5 These lymphomas generally show CD4− and CD8+ phenotype; however, ‘double negative’ CD4− and CD8− cases are also reported. Natural killer cell-associated antigens such as CD16, CD56 and CD57 are frequently expressed, although not all cases of HSαβTCL, including those with CD4− and CD8+ cytotoxic T-cell phenotype, express granzyme B. Clinical presentation has been reported to be similar to that described previously for HSγδTCL, except for the female preponderance and age distribution – some younger and older patients.5 Here, we report a patient with HSαβTCL whose lymphoma was resistant to high-dose chemotherapy with autologous peripheral blood stem cells (PBSC) rescue, and was successfully treated by allogeneic bone marrow transplantation .

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References

  1. Farcet JP, Gaulard P, Marolleau JP, Le Couedic JP, Henni T, Gourdin MF et al. Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor gamma delta. Blood 1990; 75: 2213–2219.

    CAS  PubMed  Google Scholar 

  2. Gaulard P, Bourquelot P, Kanavaros P, Haioun C, Le Couedic JP, Divine M et al. Expression of the alpha/beta and gamma/delta T-cell receptors in 57 cases of peripheral T-cell lymphomas. Identification of a subset of gamma/delta T-cell lymphomas. Am J Pathol 1990; 137: 617–628.

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Belhadj K, Reyes F, Farcet JP, Tilly H, Bastard C, Angonin R et al. Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. Blood 2003; 102: 4261–4269.

    Article  CAS  Google Scholar 

  4. Weidmann E . Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia 2000; 14: 991–997.

    Article  CAS  Google Scholar 

  5. Macon WR, Levy NB, Kurtin PJ, Salhany KE, Elkhalifa MY, Casey TT et al. Hepatosplenic alphabeta T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas. Am J Surg Pathol 2001; 25: 285–296.

    Article  CAS  Google Scholar 

  6. Cooke CB, Krenacs L, Stetler-Stevenson M, Greiner TC, Raffeld M, Kingma DW et al. Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic gamma delta T-cell origin. Blood 1996; 88: 4265–4274.

    CAS  PubMed  Google Scholar 

  7. Gassas A, Kirby M, Weitzman S, Ngan B, Abla O, Doyle JJ . Hepatosplenic gammadelta T-cell lymphoma in a 10-year-old boy successfully treated with hematopoietic stem cell transplantation. Am J Hematol 2004; 75: 113–114.

    Article  Google Scholar 

  8. Ooi J, Iseki T, Adachi D, Yamashita T, Tomonari A, Tojo A et al. Successful allogeneic bone marrow transplantation for hepatosplenic gammadelta T cell lymphoma. Haematologica 2001; 86: E25.

    CAS  PubMed  Google Scholar 

  9. Sakai R, Fujisawa S, Fujimaki K, Kanamori H, Ishigatsubo Y . Long-term remission in a patient with hepatosplenic gammadelta T cell lymphoma after cord blood stem cell transplantation following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 2006; 37: 537–538.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

    T Machino, Y Okoshi, S Kaneko, N Obara, H Y Mukai, K Suzukawa, Y Hasegawa, H Kojima & T Nagasawa

  2. Pathology of Biological Response, Nagoya University School of Medicine, Nagoya, Aichi, Japan,

    Y Yamashita & N Mori

Authors
  1. T Machino
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  2. Y Okoshi
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  3. S Kaneko
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  10. H Kojima
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Correspondence to Y Okoshi.

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Machino, T., Okoshi, Y., Kaneko, S. et al. Hepatosplenic αβ T-cell lymphoma successfully treated with allogeneic bone marrow transplantation. Bone Marrow Transplant 39, 513–514 (2007). https://doi.org/10.1038/sj.bmt.1705615

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