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Post-Transplant Events

Clonal cytogenetic changes and myeloma relapse after reduced intensity conditioning allogeneic transplantation

Bone Marrow Transplantation volume 37, pages 511–515 (2006)Cite this article

Abstract

To identify a correlation between metaphase cytogenetics and relapse after reduced intensity conditioning (RIC) allotransplant for patients with multiple myeloma, data on 60 patients (median age 52) who received grafts from a sibling (n=49) or unrelated donor (n=11) were analyzed. Fifty-three patients (88%) showed chromosomal abnormalities (CA) before the allotransplant, including 42 with abnormalities involving 13q (CA13). Twenty-two patients (41%) relapsed post-allotransplant at a median of 165 days. Of these, 11 patients showed abnormal cytogenetics at the time of post-allotransplant relapse at a median of 167 days. Of 54 patients who developed graft-versus-host disease, relapse occurred in 19 of 48 patients (43%) with CA present before RCI allotransplant, versus 1 of 6 without CA (17%) (P=0.06). Loss of CA before RIC allotransplant and disease status>PR after RIC allotransplant were significantly associated with a lower risk of post-allotransplant relapse with cytogenetic abnormalities; 5.2 vs 36%, and 18 vs 53%, (both P<0.05), respectively. The current data suggests that myeloma associated with persistent clonal cytogenetic abnormalities is an entity which most likely escapes the effects of a graft versus myeloma activity, maybe because of acquisition of resistance to immunologic manipulations.

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Authors and Affiliations

  1. The Myeloma Institute for Research and Therapy, The University of Arkansas for Medical Sciences, Little Rock, AR, USA

    C-K Lee, M Zangari, A Fassas, R Thertulien, G Talamo, A Badros, M Cottler-Fox, F van Rhee, B Barlogie & G Tricot

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  1. C-K Lee
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  2. M Zangari
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  3. A Fassas
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  4. R Thertulien
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  5. G Talamo
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  6. A Badros
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  7. M Cottler-Fox
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  8. F van Rhee
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  9. B Barlogie
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  10. G Tricot
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Correspondence to C-K Lee.

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Lee, CK., Zangari, M., Fassas, A. et al. Clonal cytogenetic changes and myeloma relapse after reduced intensity conditioning allogeneic transplantation. Bone Marrow Transplant 37, 511–515 (2006). https://doi.org/10.1038/sj.bmt.1705267

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