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Pediatric Transplants

Long-term outcome of allogeneic PBSC transplantation in pediatric patients with hematological malignancies: a report of the Spanish Working Party for Blood and Marrow Transplantation in Children (GETMON) and the Spanish Group for Allogeneic Peripheral Blood Transplantation (GETH)

Bone Marrow Transplantation volume 36, pages 781–785 (2005)Cite this article

Summary:

We analyzed the clinical outcome in 90 children undergoing allogeneic PBSC transplantation from HLA-identical relative for leukemia. GvHD prophylaxis was CsA+ methotrexate in 50 and CsA±steroids in 40. Median CD34+ cells infused were 6 × 106/kg (range, 1.4–32). Median follow-up was 60 months (range, 6–115). CI of transplant-related mortality (TRM) was 18.4±4%. On multivariate analysis, high Lansky score (>80) at transplantation was associated with lower TRM (HR, 0.9; P<0.0002). Relapse incidence (RI) was 33.6±6%. On multivariate analysis, high Lansky score at transplantation and cGvHD were associated with lower RI (HR, 0.04; P<0.0005 and HR, 0.23; P<0.03, respectively). Disease-free survival (DFS) was 57.8±5%. Disease status at transplantation (HR, 0.33; P<0.02), steroid treatment at day +90 (HR, 5.61; P<0.005) and cGvHD (HR, 0.23; P<0.005) had a significant impact on DFS in multivariate analysis. CI of cGvHD was 63.7±7%. Patients with cGvHD had better DFS (65±5%) because of lower RI (15.7±6%) and similar TRM (27.4±4%). These data suggest acceptable long-term outcomes after allogeneic PBSC transplantation in children despite the high incidence of cGvHD. These patients had a lower risk of relapse and a better DFS.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Hematology Oncology, Hospital Infantil ‘Niño Jesus’, Madrid, Spain

    M A Diaz, M Gonzalez-Vicent & L Madero

  2. Department of Pediatric Hematology, Hospital ‘Carlos Haya’, Malaga, Spain

    M E Gonzalez

  3. Department of Pediatric Hematology Oncology, Hospital ‘La Fe’, Valencia, Spain

    A Verdeguer & J de la Rubia

  4. Department of Pediatric Hematology Oncology, Hospital ‘La Paz’, Madrid, Spain

    A Martinez

  5. Department of Pediatric Hematology, Hospital ‘Virgen del Rocio’, Sevilla, Spain

    M Perez-Hurtado

  6. Department of Hematology, Hospital ‘San Pau’, Barcelona, Spain

    I Badell & S Brunet

  7. Department of Hematology, Hospital ‘Son Dureta’, Mallorca, Spain

    J Bargay

  8. Department of Hematology, Hospital ‘Gral de Murcia’, Spain

    F de Arriba

  9. Department of Hematology, Hospital ‘Gregorio Marañon’, Madrid, Spain

    J L Diez

  10. Department of Hematology, Hospital Clinico Universitario, Salamanca, Spain

    D Caballero

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  1. M A Diaz
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  11. J L Diez
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  13. L Madero
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  14. S Brunet
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Correspondence to M A Diaz.

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Diaz, M., Gonzalez-Vicent, M., Gonzalez, M. et al. Long-term outcome of allogeneic PBSC transplantation in pediatric patients with hematological malignancies: a report of the Spanish Working Party for Blood and Marrow Transplantation in Children (GETMON) and the Spanish Group for Allogeneic Peripheral Blood Transplantation (GETH). Bone Marrow Transplant 36, 781–785 (2005). https://doi.org/10.1038/sj.bmt.1705135

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