Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Unrelated cord blood transplantation for a human immunodeficiency virus-1-seropositive patient with acute lymphoblastic leukemia

Bone Marrow Transplantation volume 36, pages 261–262 (2005)Cite this article

The concurrent use of highly active antiretroviral therapy (HAART) improves results of high-dose chemotherapy with autologous stem cell transplantation (SCT) for human immunodeficiency virus-1 (HIV)-associated lymphomas.1 Recently, successful allogeneic SCT from HLA-matched sibling donors was reported in HIV-infected patients.2, 3, 4 Here, we describe the first case of an HIV-infected patient with acute lymphoblastic leukemia (ALL) who underwent umbilical cord blood transplantation (CBT).

CBT for adults has been associated with a high rate of early transplantation-related mortality (TRM).5, 6 However, our single-institution experience showed a 1-year TRM of 9% and 2-year disease-free survival of 74% in 68 adults after CBT.7 Both CB donors and the patient in the present study were Japanese. The lesser genetic diversity in a single ethnic population in our studies might be associated with the favorable outcomes of CBT, such as the lower rates of severe acute GVHD. Although our results suggest that CBT is feasible for HIV-infected patients on HAART, the safety and efficacy should be further examined by prospective studies.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Krishnan A, Zaia J, Forman SJ . Should HIV-positive patients with lymphoma be offered stem cell transplants? Bone Marrow Transplant 2003; 32: 741–748.

    Article  CAS  Google Scholar 

  2. Schlegel P, Beatty P, Halvorsen R, McCune J . Successful allogeneic bone marrow transplant in an HIV-1-positive man with chronic myelogenous leukemia. J Acquir Immune Defic Syndr 2000; 24: 289–290.

    Article  CAS  Google Scholar 

  3. Sora F, Antinori A, Piccirillo N et al. Highly active antiretroviral therapy and allogeneic CD34(+) peripheral blood progenitor cells transplantation in an HIV/HCV coinfected patient with acute myeloid leukemia. Exp Hematol 2002; 30: 279–284.

    Article  CAS  Google Scholar 

  4. Kang EM, de Witte M, Malech H et al. Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome. Blood 2002; 99: 698–701.

    Article  CAS  Google Scholar 

  5. Laughlin MJ, Eapen M, Rubinstein P et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004; 351: 2265–2275.

    Article  CAS  Google Scholar 

  6. Rocha V, Labopin M, Sanz G et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004; 351: 2276–2285.

    Article  CAS  Google Scholar 

  7. Takahashi S, Iseki T, Ooi J et al. Single institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematological malignancies. Blood 2004; 104: 3813–3820.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    A Tomonari, S Takahashi, Y Shimohakamada, J Ooi, K Takasugi, N Ohno, T Konuma, K Uchimaru, A Tojo & S Asano

  2. Department of Infectious Diseases and Applied Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    T Odawara, T Nakamura & A Iwamoto

Authors
  1. A Tomonari
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y Shimohakamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Ooi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K Takasugi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N Ohno
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T Konuma
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. K Uchimaru
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Tojo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. T Odawara
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. T Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. A Iwamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. S Asano
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tomonari, A., Takahashi, S., Shimohakamada, Y. et al. Unrelated cord blood transplantation for a human immunodeficiency virus-1-seropositive patient with acute lymphoblastic leukemia. Bone Marrow Transplant 36, 261–262 (2005). https://doi.org/10.1038/sj.bmt.1705028

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1705028

This article is cited by

Search

Advanced search

Quick links