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Avoidance of Toxoplasma gondii transmission from a recently infected donor to the recipient of hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 35, pages 735–736 (2005)Cite this article

Toxoplasmosis is a potentially life-threatening opportunistic infection after hematopoietic stem cell transplantation (HSCT).1 It usually results from reactivation of latent infection in patients seropositive for Toxoplasma before transplantation, but transmission from the donor via the graft has been described.2, 3, 4

A 44-year-old Algerian woman who had been in France for 2 years required allogeneic HSCT for relapsed AML from her HLA-identical brother in Algeria. The donor's pre-transplant Toxoplasma IgG antibody was positive and the IgM titer was very high. Diagnosis of recent toxoplasmosis was based on the serological profile (Table 1).5 The recipient's T. gondii serostatus was negative. Nevertheless, a decision was made to proceed with the allograft for medical reasons (recipient) and logistic reasons (donor). The aim of subsequent interventions and monitoring was to prevent toxoplasmosis in the recipient.

Table 1 Serial donor and recipient Toxoplasma serology and PCR
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Acknowledgements

We are indebted to S Durville for linguistic assistance.

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Authors and Affiliations

  1. Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire, Grenoble, France

    M P Brenier-Pinchart, H Fricker-Hidalgo & H Pelloux

  2. Département de Cancérologie et d'Hématologie, Centre Hospitalier Universitaire, Grenoble, France

    F Garban & C Makowski

  3. Unité Mixte de Thérapie Cellulaire et Tissulaire, Centre Hospitalier Universitaire, Grenoble, France

    M J Richard

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  1. M P Brenier-Pinchart
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  2. F Garban
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  6. H Pelloux
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Brenier-Pinchart, M., Garban, F., Fricker-Hidalgo, H. et al. Avoidance of Toxoplasma gondii transmission from a recently infected donor to the recipient of hematopoietic stem cell transplantation. Bone Marrow Transplant 35, 735–736 (2005). https://doi.org/10.1038/sj.bmt.1704879

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