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Graft-Versus-Host Disease

Delayed or delayed sequential bone marrow transplantation: relevance for acute graft-versus-host disease prevention after major H2 incompatible transplantation

Bone Marrow Transplantation volume 35, pages 803–806 (2005)Cite this article

Summary:

During this study, BalB/C mice were used as recipients and C57 bl/6 mice as donors. Recipients were given 800 cGys of total body irradiation (TBI) on day 0. Transplantation was carried out as follows: group (1): TBI on day 0; group (2): TBI on day 0 and transplantation on day +1; group (3): TBI on day 0 and transplantation on day 4; group (4): TBI on day 0 and transplantation started from day 4 through day 8. Mice that received TBI only died by day 11. All group 2 mice developed aGVHD and died by day +15. In total, 70% of group 3 were still surviving by day 60 (P<0.001, compared to day +1 transplantation). Survival rates were 90% at day 60 for group 4 (P<0.001 compared to day 1 transplantation). No survival advantage was found between animals transplanted on day 4 and animals with delayed sequential transplantation (P=0.1). Significant engraftment was found in both groups 3 and 4, with no significant differences in the percentages of donor-derived cells between the two groups (P>0.05). These data demonstrate that either delayed or delayed sequential transplantation after TBI can be an effective approach for aGVHD prevention.

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Authors and Affiliations

  1. Hematology and Medical Oncology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    M Mabed

  2. Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    S Maroof

  3. Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    K Zalta

  4. Radiotherapy Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    M El-Awadee

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  1. M Mabed
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  2. S Maroof
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  4. M El-Awadee
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Correspondence to M Mabed.

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Mabed, M., Maroof, S., Zalta, K. et al. Delayed or delayed sequential bone marrow transplantation: relevance for acute graft-versus-host disease prevention after major H2 incompatible transplantation. Bone Marrow Transplant 35, 803–806 (2005). https://doi.org/10.1038/sj.bmt.1704877

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