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Evidence of graft-versus-tumour effect following allogeneic haematopoietic stem cell transplantation in renal cancer other than clear cell type

Bone Marrow Transplantation volume 34, pages 917–918 (2004)Cite this article

Several studies have demonstrated that allogeneic haematopoietic stem cell transplantation has potent antitumour effect not only against haematological but also against solid malignancies.1 Main evidence of the potency of GVT effect is represented by sustained remissions obtained after NST in patients with metastatic renal cell carcinoma (RCC) refractory to conventional cytokine-based immunotherapy.2, 3 This evidence supports the notion that RCC harbours immunogenic peculiarities4, 5, 6 that render this tumour responsive to immunotherapies.7 Interestingly, only clear cell carcinoma, but not other RCC histotypes, has been reported to respond to NST.2, 8, 9 Whether this is due to the small number of patients receiving NST for RCC other than those of the clear cell type or due to a real resistance of other histotypes remains to be defined. We have observed objective tumour response following NST in a patient with metastatic papillary RCC.

A 56 year-old male underwent right nephrectomy for stage II (AJCC criteria-VI Ed.) papillary renal carcinoma. After 5 years in June 2002, he relapsed in lungs, and left laterocervical as well as mediastinal lymph nodes. Biopsy of laterocervical lymph node confirmed the diagnosis of metastatic papillary renal carcinoma. From July 2002 to October 2002, he received treatment with 5-fluorouracil, interleukin-2 and α-interferon with progression of disease. In January 2003, after signing informed consent, he received NST from his 72 year-old HLA-identical brother according to the European Blood and Marrow Transplantation (EBMT) phase I NST protocol for refractory solid tumours, approved by the Ethical Committee of Ospedale Niguarda Ca' Granda.

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  1. SC Divisione Oncologia Medica Falck and Radiologia, Ospedale Niguarda Ca' Granda, Milano, Italy

    S Secondino, P Pedrazzoli, L Giannetta, I Schiavetto, A Vanzulli & S Siena

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  1. S Secondino
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  2. P Pedrazzoli
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  3. L Giannetta
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  5. A Vanzulli
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  6. S Siena
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Secondino, S., Pedrazzoli, P., Giannetta, L. et al. Evidence of graft-versus-tumour effect following allogeneic haematopoietic stem cell transplantation in renal cancer other than clear cell type. Bone Marrow Transplant 34, 917–918 (2004). https://doi.org/10.1038/sj.bmt.1704669

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