Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Horse antilymphocytic globulin in hepatitis B exacerbation after bone marrow transplantation adoptive immunity transfer

Bone Marrow Transplantation volume 33, pages 1057–1059 (2004)Cite this article

Summary:

We describe the case of a HBsAg+, HBeAg+ carrier, treated with lamivudine, who experienced exacerbation of hepatitis after BMT from an anti-HBs+, anti-HBc+, anti-HBe+ donor. The serological profile of the donor and the timing of exacerbation suggested that the adoptive immunity transfer played a major pathogenetic role. Antilymphocyte globulin administration resulted in resolution of hepatitis and seroconversion to anti-HBs+. Therapy aimed at blocking the effector arm of liver damage could represent a novel approach to avoid the risk of progression to fulminant hepatitis without hampering the chances of recovery from hepatitis B.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Chen PM, Chiou TJ, Fan FS et al. Fulminant hepatitis is significantly increased in hepatitis B carriers after allogeneic bone marrow transplantation. Transplantation 1999; 67: 1425–1433.

    Article  CAS  Google Scholar 

  2. Lau GKK, Liang R, Wu PC et al. Use of famciclovir to prevent HBV reactivation in HBsAg-positive recipients after allogeneic bone marrow transplantation. J Hepatol 1998; 28: 359–368.

    Article  CAS  Google Scholar 

  3. Perillo RP . Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology 2001; 120: 1009–1022.

    Article  Google Scholar 

  4. Chiba T, Yokosuka O, Goto S et al. Successful clearance of hepatitis B virus after allogeneic stem cell transplantation: beneficial combination of adoptive immunity transfer and lamivudine. Eur J Haematol 2003; 71: 220–223.

    Article  Google Scholar 

  5. Lau GKK, Lok ASF, Liang RHS et al. Clearance of hepatitis B surface antigen after bone marrow transplantation: role of adoptive immunity transfer. Hepatology 1997; 25: 1497–1501.

    Article  CAS  Google Scholar 

  6. Colloredo Mels G, Bellati G, Leandro G et al. Quantitative analysis of IgM anti-HBc in chronic hepatitis B patients using a new ‘gray-zone’ for the evaluation of ‘borderline’ value. J Hepatol 1996; 25: 644–648.

    Article  Google Scholar 

  7. Strasser SI, McDonald SJ, Schoch G et al. Severe hepatocellular injury after hematopoietic cell transplant: incidence and etiology in 2136 consecutive patients. Hepatology 2000; 32: 299A.

    Article  Google Scholar 

  8. Guidotti LG, Rochford R, Chung J et al. Viral clearance without destruction of infected cell during acute HBV infection. Science 1999; 284: 825–829.

    Article  CAS  Google Scholar 

  9. Maini MK, Boni C, Lee CK et al. The role of virus specific CD8+ cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med 2000; 191: 1269–1280.

    Article  CAS  Google Scholar 

  10. Kakimi K, Lane TE, Wieland S et al. Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. J Exp Med 2001; 194: 1755–1766.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Unità Trapianto di Midollo, Clinica Pediatrica I, Italy

    C Favre, M C Menconi, M Nardi, G Casazza & P Macchia

  2. UO Gastroenterologia ed Epatologia, Azienda Ospedaliera-Universitaria Pisana, Pisa, Italy

    F Oliveri, F Bonino & M R Brunetto

Authors
  1. C Favre
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M C Menconi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Nardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G Casazza
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F Oliveri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P Macchia
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F Bonino
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M R Brunetto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C Favre.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Favre, C., Menconi, M., Nardi, M. et al. Horse antilymphocytic globulin in hepatitis B exacerbation after bone marrow transplantation adoptive immunity transfer. Bone Marrow Transplant 33, 1057–1059 (2004). https://doi.org/10.1038/sj.bmt.1704471

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704471

Keywords

Search

Advanced search

Quick links