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A myeloablative allograft after rejection of two consecutive nonmyeloablative transplants from two different HLA identical siblings

Bone Marrow Transplantation volume 33, pages 659–660 (2004)Cite this article

Summary:

A 55-year-old female with standard risk AML in second CR received an allogenic transplant from an HLA-matched sibling, using a nonmyeloablative conditioning regimen (NMST). On day +139, she rejected her graft with autologous reconstitution. She received a second NMST from a different HLA-matched sibling with an identical conditioning regimen and immunosuppression. On day +110, she rejected the second graft, with autologous reconstitution with blasts. She received a third allograft from the first sibling with a myeloablative busulfan-based conditioning regimen. She is now day +270, in CR, with full donor chimerism.

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Authors and Affiliations

  1. UO Ematologia, Università degli Studi di Pisa e Azienda Ospedaliera Pisana, Italy

    F Papineschi, E Benedetti, S Galimberti, F Caracciolo, R Fazzi & M Petrini

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  1. F Papineschi
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  2. E Benedetti
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  3. S Galimberti
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  4. F Caracciolo
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  5. R Fazzi
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  6. M Petrini
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Correspondence to F Papineschi.

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Papineschi, F., Benedetti, E., Galimberti, S. et al. A myeloablative allograft after rejection of two consecutive nonmyeloablative transplants from two different HLA identical siblings. Bone Marrow Transplant 33, 659–660 (2004). https://doi.org/10.1038/sj.bmt.1704356

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  • DOI: https://doi.org/10.1038/sj.bmt.1704356

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