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T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation

Summary:

A 61-year-old man with angioimmunoblastic lymphoma in first complete remission underwent autologous peripheral blood stem cell transplantation. At 1 month post transplant, asymptomatic large granular lymphocytosis developed. The surface marker profile of the cells was CD3+CD8+CD56−CD57+. The disease course was chronic and indolent. The patient remains in complete remission from angioimmunoblastic lymphoma more than 6 months post transplant with persistent large granular lymphocytosis (lymphocyte count, 5–15 × 109/l). Although post transplantation T-cell lymphoproliferative disorders have mostly occurred in allogeneic transplantation recipients and presented as aggressive lymphomas/leukemias, we suggest that chronic indolent T-cell large granular lymphocytic leukemia can occur after autologous stem cell transplantation.

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Acknowledgements

This work was funded in part by a grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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Correspondence to K Kojima.

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Narumi, H., Kojima, K., Matsuo, Y. et al. T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 33, 99–101 (2004). https://doi.org/10.1038/sj.bmt.1704298

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  • DOI: https://doi.org/10.1038/sj.bmt.1704298

Keywords

  • T-cell large granular lymphocytic leukemia
  • post transplantation lymphoproliferative disorders
  • autologous peripheral blood stem cell transplantation

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