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T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation

Bone Marrow Transplantation volume 33, pages 99–101 (2004)Cite this article

Summary:

A 61-year-old man with angioimmunoblastic lymphoma in first complete remission underwent autologous peripheral blood stem cell transplantation. At 1 month post transplant, asymptomatic large granular lymphocytosis developed. The surface marker profile of the cells was CD3+CD8+CD56−CD57+. The disease course was chronic and indolent. The patient remains in complete remission from angioimmunoblastic lymphoma more than 6 months post transplant with persistent large granular lymphocytosis (lymphocyte count, 5–15 × 109/l). Although post transplantation T-cell lymphoproliferative disorders have mostly occurred in allogeneic transplantation recipients and presented as aggressive lymphomas/leukemias, we suggest that chronic indolent T-cell large granular lymphocytic leukemia can occur after autologous stem cell transplantation.

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References

  1. Semenzato G, Zambello R, Starkebaum G et al. The lymphoproliferative disease of granular lymphocytes: updated criteria for diagnosis. Blood 1997; 89: 256–260.

    CAS  PubMed  Google Scholar 

  2. Nalesnik MA . Posttransplantation lymphoproliferative disorders (PTLD): current perspectives. Semin Thorac Cardiovasc Surg 1996; 8: 139–148.

    CAS  PubMed  Google Scholar 

  3. Deeg HJ, Socie G . Malignancies after hematopoietic stem cell transplantation: many questions, some answers. Blood 1998; 91: 1833–1844.

    CAS  PubMed  Google Scholar 

  4. Macon WR, Williams ME, Greer JP et al. Natural killer-like T-cell lymphomas: aggressive lymphomas of T-large granular lymphocytes. Blood 1996; 87: 1474–1483.

    CAS  PubMed  Google Scholar 

  5. Hanson MN, Morrison VA, Peterson BA et al. Posttransplant T-cell lymphoproliferative disorders – an aggressive, late complication of solid-organ transplantation. Blood 1996; 88: 3626–3633.

    CAS  PubMed  Google Scholar 

  6. Lones MA, Kirov I, Said JW et al. Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient. Bone Marrow Transplant 2000; 26: 1021–1024.

    Article  CAS  PubMed  Google Scholar 

  7. Jenkins D, DiFrancesco L, Chaudhry A et al. Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients. Bone Marrow Transplant 2002; 30: 321–326.

    Article  CAS  PubMed  Google Scholar 

  8. Yufu Y, Kimura M, Kawano R et al. Epstein–Barr virus-associated T cell lymphoproliferative disorder following autologous blood stem cell transplantation for relapsed Hodgkin's disease. Bone Marrow Transplant 2000; 26: 1339–1341.

    Article  CAS  PubMed  Google Scholar 

  9. Morice WG, Kurtin PJ, Leibson PJ et al. Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B. Blood 2002; 99: 268–274.

    Article  CAS  PubMed  Google Scholar 

  10. Gentile TC, Hadlock KG, Uner AH et al. Large granular lymphocyte leukaemia occurring after renal transplantation. Br J Haematol 1998; 101: 507–512.

    Article  CAS  PubMed  Google Scholar 

  11. Feher O, Barilla D, Locker J et al. T-cell large granular lymphocytic leukemia following orthotopic liver transplantation. Am J Hematol 1995; 49: 216–220.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was funded in part by a grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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Authors and Affiliations

  1. The First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan

    H Narumi, K Kojima, H Shikata, H Niiya, T Azuma, Y Yakushijin, I Sakai, M Yasukawa & S Fujita

  2. Fujisaki Cell Center, Hayashibara Biochemical Labs Inc., Okayama, Japan

    Y Matsuo

  3. Department of Clinical Laboratory Medicine, Ehime University School of Medicine, Ehime, Japan

    K Sekiya, T Niiya & S Bando

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  1. H Narumi
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  2. K Kojima
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  3. Y Matsuo
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  4. H Shikata
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  6. T Niiya
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  8. H Niiya
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  9. T Azuma
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  11. I Sakai
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  12. M Yasukawa
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  13. S Fujita
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Correspondence to K Kojima.

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Narumi, H., Kojima, K., Matsuo, Y. et al. T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 33, 99–101 (2004). https://doi.org/10.1038/sj.bmt.1704298

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  • DOI: https://doi.org/10.1038/sj.bmt.1704298

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