Abstract
PHARMACOLOGICAL and toxicological actions of dart poison have received a great deal of attention in the past. Among the contributors on this subject were Ridley1, Chopra and de Premankur2 and Doebel et al.3. It was generally assumed that the chief toxic agent in the dart was the digitalis-like substance contained in the latex of the Upas tree Antiarias toxicaria, with which some dart poison was known to be made (Burkill4, and Chen et al.5). The present communication puts on record some observations of the pharmacological and toxicological actions of a dart poison obtained recently from the Sakais in Perak, North Malaya. A water extract of the dart poison was prepared by dissolving the poison of one dart in 1 c.c. of water. It was filtered before use for the experiment.
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References
Ridley, H. N., J. Trop. Med. and Hyg., 33, 185 (1930).
Chopra, R. N., and de Premankur, Ind. J. Med. Res., 21, 513 (1934).
Doebel, K., Schlitter, E., and Reichstein, T., Helv. Chim. Acta, 31, 688 (1948).
Burkill, I. H., “A Dictionary of the Economic Products of the Malay Peninsula”, 174–184 (1935).
Chen, K. K., Anderson, R. C., and Brown, Robbins, J. Amer. Pharm. Assoc., 26, 215 (1937).
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CHUN YU LIN, R. Pharmacological and Texicological Actions of Dart Poison used in Malaya. Nature 170, 416 (1952). https://doi.org/10.1038/170416a0
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DOI: https://doi.org/10.1038/170416a0
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