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Seminoma

High-dose chemotherapy as salvage treatment for seminoma

Bone Marrow Transplantation volume 30, pages 157–160 (2002)Cite this article

Abstract

Between October 1989 and February 1997, 13 patients with refractory or relapsed seminomas were treated with high-dose chemotherapy (HDCT) as part of consecutive phase I/II studies. Six patients had failed prior cisplatin-based first-line treatments and seven patients had also failed cisplatin-based salvage treatments. After HDCT 4/12 (33%) patients became disease-free, 4/12 (33%) patients achieved partial remissions and 4/12 (33%) patients suffered progressive disease despite HDCT. One patient developed multiorgan failure and died. With a median follow-up of 4.5 years (range 3.4 to 8 years) five patients (38%) are alive and eight patients (62%) have died. Patients with non-pulmonary visceral metastases, with short relapse-free intervals and with cisplatin-refractory tumors were more likely to fail. HDCT can be curative in seminoma patients even if offered as second salvage treatment.

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Authors and Affiliations

  1. Medizinische Klinik mit Schwerpunkt Hämatologie/Onkologie, Universitätsklinikum Charité, Campus Virchow-Klinikum, Berlin, Germany

    O Rick, W Siegert, N Schwella, M Dubiel & A Krusch

  2. Klinik für Hämatologie und Onkologie, Klinikum der Philipps Universität, Marburg, Germany

    J Beyer

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  1. O Rick
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  2. W Siegert
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  3. N Schwella
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  4. M Dubiel
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  5. A Krusch
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Rick, O., Siegert, W., Schwella, N. et al. High-dose chemotherapy as salvage treatment for seminoma. Bone Marrow Transplant 30, 157–160 (2002). https://doi.org/10.1038/sj.bmt.1703623

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