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Successful autologous peripheral blood stem cell transplantation in transformed follicular lymphoma previously treated with radioimmunotherapy (iodine 131I tositumomab)

Bone Marrow Transplantation volume 29, pages 523–525 (2002)Cite this article

Abstract

While the use of radioimmunotherapy for lymphoma increases, the feasibility and efficacy of autologous stem cell transplant for subsequent relapse remains unknown. We report a 48-year-old male with transformed follicular mixed non-Hodgkin's lymphoma. After treatment with three different combination chemotherapy regimens, at relapse he received radioimmunotherapy with iodine 131I tositumomab (anti-CD20), with very good response. At later relapse, a second course of 131I tositumomab was given unsuccessfully. He underwent peripheral blood stem cell harvest, chemoradiotherapy conditioning and autologous transplantation with prompt engraftment and without significant complications. He remains in complete remission with normal blood counts 25 months post autograft.

Bone Marrow Transplantation (2002) 29, 523–525. doi:10.1038/sj.bmt.1703398

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References

  1. Hubbard SM, Chabner BA, DeVita VT Jr et al. Histologic progression in non-Hodgkin's lymphoma Blood 1982 59: 258 264

    CAS  Google Scholar 

  2. Chen CI, Crump M, Tsang R et al. Autotransplants for histologically transformed follicular non-Hodgkin's lymphoma Br J Haematol 2001 113: 202 208

    Article  CAS  Google Scholar 

  3. Williams CD, Harrison CN, Lister TA et al. European Bone Marrow Transplant Lymphoma Working Party. High-dose therapy and autologous stem-cell support for chemosensitive transformed low-grade follicular non-Hodgkin's lymphoma: a case-matched study from the European Bone Marrow Transplant Registry J Clin Oncol 2001 19: 727 735

    Article  CAS  Google Scholar 

  4. Press OW, Eary JF, Gooley T et al. A phase I–II trial of iodine-131-tositumomab (anti-CD20), etoposide, cyclophosphamide, and autologous stem cell transplantation for relapsed B-cell lymphomas Blood 2000 96: 2934 2942

    CAS  Google Scholar 

  5. Kaminiski MS, Estes J, Zasadny KR et al. Radioimmunotherapy with iodine (131)I tositumomab for relapsed or refractory B-cell non-Hodgkin lymphoma: updated results and long-term follow-up of the University of Michigan experience Blood 2000 96: 1259 1266

    Google Scholar 

  6. Vose JM, Wahl RL, Saleh M et al. Multicenter phase II study of iodine-131 tositumomab for chemotherapy relapsed or refractory low-grade and transformed low-grade B-cell non-Hodgkin's lymphoma J Clin Oncol 2000 18: 1316 1323

    Article  CAS  Google Scholar 

  7. Witzig TE, White CA, Wiseman GA et al. Phase I/II trial of IDEC-Y2B8 radioimmunotherapy for treatment of relapsed or refractory CD20(+) B-cell non-Hodgkin's lymphoma J Clin Oncol 1999 12: 3793 3803

    Article  Google Scholar 

  8. Leone G, Mele L, Pulsoni A et al. L The incidence of secondary leukemias Haematologica 1999 84: 937 945

    CAS  PubMed  Google Scholar 

  9. Metayer C, Curtis RE, Sobocinski KA et al. Myelodysplastic syndrome (MDS) and leukemia after autotransplantation for lymphoma: a multicenter case-control study. Oral Presentation No. 23 Proc ASCO 2001 20: 7a

    Google Scholar 

  10. Park S, Brice P, Noguerra ME et al. Myelodysplasias and leukemias after autologous stem cell transplantation for lymphoid malignancies Bone Marrow Transplant 2000 26: 321 326

    Article  CAS  Google Scholar 

  11. Stone RM, Neuberg D, Soiffer R et al. Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma J Clin Oncol 1994 12: 2535 2542

    Article  CAS  Google Scholar 

  12. Milligan DW, Ruiz de Elvira CM, Kolb H-J et al. Secondary leukaemia and myelodysplasia after autografting for lymphoma: results from the EBMT. EBMT Lymphoma and Late Effects Working Parties. European Group for Blood and Marrow Transplantation Br J Haematol 1999 106: 1020 1026

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. University of Loyola Medical Center, Maywood, IL, USA

    J Cooney & P Stiff

  2. University of Michigan, Ann Arbor, MI, USA

    M Kaminski

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  1. J Cooney
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  2. P Stiff
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  3. M Kaminski
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Cooney, J., Stiff, P. & Kaminski, M. Successful autologous peripheral blood stem cell transplantation in transformed follicular lymphoma previously treated with radioimmunotherapy (iodine 131I tositumomab). Bone Marrow Transplant 29, 523–525 (2002). https://doi.org/10.1038/sj.bmt.1703398

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