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Second hematopoietic stem cell transplantation for the treatment of graft failure, graft rejection or relapse after allogeneic transplantation

Bone Marrow Transplantation volume 29, pages 545–552 (2002)Cite this article

Abstract

Failure to engraft after hematopoietic stem cell transplantation (graft dysfunction) or to sustain engraftment (graft rejection) is a formidable complication due to many possible factors. These include inadequate stem cell numbers, infections, graft-versus-host disease and immunological mediated processes. Fortunately, this complication is uncommon and can be overcome by additional hematopoietic stem cell infusions. Multiple treatment alternatives have been explored including hematopoietic growth factors, additional infusions of stem cells alone, with augmented immunosuppression or with additional cytotoxic therapy. Various sources of the additional stem cells are feasible including the original donor, using another donor, using stem cells collected from the marrow or after cytokine mobilization from the peripheral blood. This report will overview this complication and review the various studies that have attempted to define both cause and therapy. However, a lack of well-designed prospective studies has made definitive recommendations difficult although basic principles have been established.

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References

  1. Blau IW, Basara N, Serr A et al. A second unrelated bone marrow transplant: successful quantitative monitoring of mixed chimerism using a highly discriminative PCR-STR system Clin Lab Haematol 1999 21: 133 138

    CAS  PubMed  Google Scholar 

  2. Thomas E, Storb R, Clift RA et al. Bone-marrow transplantation (first of two parts) New Engl J Med 1975 292: 832 843

    CAS  PubMed  Google Scholar 

  3. Thomas ED, Storb R, Clift RA et al. Bone-marrow transplantation (second of two parts) New Engl J Med 1975 292: 895 902

    CAS  PubMed  Google Scholar 

  4. Davies SM, Weisdorf DJ, Haake RJ et al. Second infusion of bone marrow for treatment of graft failure after allogeneic bone marrow transplantation Bone Marrow Transplant 1994 14: 73 77

    CAS  PubMed  Google Scholar 

  5. Donohue J, Homge M, Kernan NA . Characterization of cells emerging at the time of graft failure after bone marrow transplantation from an unrelated marrow donor Blood 1993 82: 1023 1029

    CAS  PubMed  Google Scholar 

  6. Bensinger W, Appelbaum F, Rowley S et al. Factors that influence collection and engraftment of autologous peripheral-blood stem cells J Clin Oncol 1995 13: 2547 2555

    Article  CAS  PubMed  Google Scholar 

  7. Weaver CH, Hazelton B, Birch R et al. An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy Blood 1995 86: 3961 3969

    CAS  PubMed  Google Scholar 

  8. Weaver CH, Potz J, Redmond J et al. Engraftment and outcomes of patients receiving myeloablative therapy followed by autologous peripheral blood stem cells with a low CD34+ cell content Bone Marrow Transplant 1997 19: 1103 1110

    CAS  PubMed  Google Scholar 

  9. Storb R, Prentice RL, Thomas ED et al. Factors associated with graft rejection after HLA-identical marrow transplantation for aplastic anaemia Br J Haematol 1983 55: 573 585

    CAS  PubMed  Google Scholar 

  10. Stucki A, Leisenring W, Sandmaier BM et al. Decreased rejection and improved survival of first and second marrow transplants for severe aplastic anemia (a 26-year retrospective analysis) Blood 1998 92: 2742 2749

    CAS  PubMed  Google Scholar 

  11. McCann SR, Bacigalupo A, Gluckman E et al. Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group Bone Marrow Transplant 1994 13: 233 237

    CAS  PubMed  Google Scholar 

  12. Champlin RE, Horowitz MM, van Bekkum DW et al. Graft failure following bone marrow transplantation for severe aplastic anemia: risk factors and treatment results Blood 1989 73: 606 613

    CAS  PubMed  Google Scholar 

  13. Ferster A, Corazza F, Vertongen F et al. Transplanted sickle-cell disease patients with autologous bone marrow recovery after graft failure develop increased levels of fetal haemoglobin which corrects disease severity Br J Haematol 1995 90: 804 808

    CAS  PubMed  Google Scholar 

  14. Martin PJ, Akatsuka Y, Hahne M et al. Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection Blood 1998 92: 2177 2181

    CAS  PubMed  Google Scholar 

  15. Beatty PG, Clift RA, Mickelson EM et al. Marrow transplantation from related donors other than HLA-identical siblings New Engl J Med 1985 313: 765 771

    Article  CAS  PubMed  Google Scholar 

  16. Anasetti C, Amos D, Beatty PG et al. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma New Engl J Med 1989 320: 197 204

    CAS  PubMed  Google Scholar 

  17. Beatty PG, Hansen JA, Longton GM et al. Marrow transplantation from HLA-matched unrelated donors for treatment of hematologic malignancies Transplantation 1991 51: 443 447

    CAS  PubMed  Google Scholar 

  18. Kernan NA, Bartsch G, Ash RC et al. Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program New Engl J Med 1993 328: 593 602

    CAS  PubMed  Google Scholar 

  19. McGlave P, Bartsch G, Anasetti C et al. Unrelated donor marrow transplantation therapy for chronic myelogenous leukemia: initial experience of the National Marrow Donor Program Blood 1993 81: 543 550

    CAS  PubMed  Google Scholar 

  20. Bosserman LD, Murray C, Takvorian T et al. Mechanism of graft failure in HLA-matched and HLA-mismatched bone marrow transplant recipients Bone Marrow Transplant 1989 4: 239 245

    CAS  PubMed  Google Scholar 

  21. Bunjes D, Wiesneth M, Hertenstein B et al. Graft failure after T cell-depleted bone marrow transplantation: clinical and immunological characteristics and response to immunosuppressive therapy Bone Marrow Transplant 1990 6: 309 314

    CAS  PubMed  Google Scholar 

  22. Lamb LS, Szafer F, Henslee-Downey PJ et al. Characterization of acute bone marrow graft rejection in T cell-depleted, partially mismatched related donor bone marrow transplantation Exp Hematol 1995 23: 1595 1600

    PubMed  Google Scholar 

  23. Lienert-Weidenbach K, Valiante NM, Brown C et al. Mismatches for two major and one minor histocompatibility antigen correlate with a patient's rejection of a bone marrow graft from a serologically HLA-identical sibling Biol Blood Marrow Transplant 1997 3: 255 260

    CAS  PubMed  Google Scholar 

  24. Carella AM, Champlin R, Slavin S et al. Mini-allografts: ongoing trials in humans Bone Marrow Transplant 2000 25: 345 350

    CAS  PubMed  Google Scholar 

  25. Bacigalupo A . Hematopoietic stem cell transplants after reduced intensity conditioning regimen (RI-HSCT): report of a workshop of the European group for Blood and Marrow Transplantation (EBMT) Bone Marrow Transplant 2000 25: 803 805

    CAS  PubMed  Google Scholar 

  26. Bierer BE, Emerson SG, Antin J et al. Regulation of cytotoxic T lymphocyte-mediated graft rejection following bone marrow transplantation Transplantation 1988 46: 835 839

    CAS  PubMed  Google Scholar 

  27. Petersdorf EW, Longton GM, Anasetti C et al. Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors Blood 1997 89: 1818 1823

    CAS  PubMed  Google Scholar 

  28. Petersdorf EW, Hansen JA, Martin PJ et al. Major histocompatibility complex class I alleles and antigens in hematopoietic-cell transplantation New Engl J Med 2001 345: 1794 1800

    CAS  PubMed  Google Scholar 

  29. Fleischhauer K, Kernan NA, O'Reilly RJ et al. Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44 New Engl J Med 1990 323: 1818 1822

    CAS  PubMed  Google Scholar 

  30. Marijt WA, Kernan NA, Diaz-Barrientos T et al. Multiple minor histocompatibility antigen-specific cytotoxic T lymphocyte clones can be generated during graft rejection after HLA-identical bone marrow transplantation Bone Marrow Transplant 1995 16: 125 132

    CAS  PubMed  Google Scholar 

  31. Petersdorf EW, Kollman C, Hurley CK et al. Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience Blood 2001 98: 2922 2929

    CAS  PubMed  Google Scholar 

  32. Dennert G, Anderson CG, Warner J . T killer cells play a role in allogeneic bone marrow graft rejection but not in hybrid resistance J Immunol 1985 135: 3729 3734

    CAS  PubMed  Google Scholar 

  33. Goss GD, Wittwer MA, Bezwoda WR et al. Effect of natural killer cells on syngeneic bone marrow: in vitro and in vivo studies demonstrating graft failure due to NK cells in an identical twin treated by bone marrow transplantation Blood 1985 66: 1043 1046

    CAS  PubMed  Google Scholar 

  34. Grigoriadou K, Menard C, Perarnau B et al. MHC class la molecules alone control NK-mediated bone marrow graft rejection Eur J Immunol 1999 29: 3683 3690

    CAS  PubMed  Google Scholar 

  35. Quinones RR . Hematopoietic engraftment and graft failure after bone marrow transplantation Am J Pediatr Hematol Oncol 1993 15: 3 17

    CAS  PubMed  Google Scholar 

  36. Rosenfeld CS, Rybka WB, Weinbaum D et al. Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus-6 Exp Hematol 1995 23: 626 629

    CAS  PubMed  Google Scholar 

  37. Steffens HP, Podlech J, Kurz S et al. Cytomegalovirus inhibits the engraftment of donor bone marrow cells by downregulation of hemopoietin gene expression in recipient stroma J Virol 1998 72: 5006 5015

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Johnston RE, Geretti AM, Prentice HG et al. HHV-6-related secondary graft failure following allogeneic bone marrow transplantation Br J Haematol 1999 105: 1041 1043

    CAS  PubMed  Google Scholar 

  39. Eapen M, Davies SM, Ramsay NK . Late graft rejection and second infusion of bone marrow in children with aplastic anaemia Br J Haematol 1999 104: 186 188

    CAS  PubMed  Google Scholar 

  40. Bader P, Holle W, Klingebiel T et al. Mixed hematopoietic chimerism after allogeneic bone marrow transplantation: the impact of quantitative PCR analysis for prediction of relapse and graft rejection in children Bone Marrow Transplant 1997 19: 697 702

    CAS  PubMed  Google Scholar 

  41. Cimino G, Rapanotti MC, Elia L et al. A prospective molecular study of chimaerism in patients with haematological malignancies receiving unrelated cord blood or bone marrow transplants: detection of mixed chimaerism predicts graft failure with or without early autologous reconstitution in cord blood recipients Br J Haematol 1999 104: 770 777

    CAS  PubMed  Google Scholar 

  42. Gyger M, Baron C, Forest L et al. Quantitative assessment of hematopoietic chimerism after allogeneic bone marrow transplantation has predictive value for the occurrence of irreversible graft failure and graft-vs-host disease Exp Hematol 1998 26: 426 434

    CAS  PubMed  Google Scholar 

  43. Dufour C, Dallorso S, Casarino L et al. Late graft failure 8 years after first bone marrow transplantation for severe acquired aplastic anemia Bone Marrow Transplant 1999 23: 743 745

    CAS  PubMed  Google Scholar 

  44. Bacigalupo A, Bruno B, Saracco P et al. Antilymphocyte globulin, cyciosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italiano Trapianti di Midolio Osseo (GITMO) Blood 2000 95: 1931 1934

    CAS  PubMed  Google Scholar 

  45. Marsh J, Schrezenmeier H, Marin P et al. Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: a report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anaemia Working Party Blood 1999 93: 2191 2195

    CAS  PubMed  Google Scholar 

  46. Shing MM, Vowels M . Role of second bone marrow transplants Bone Marrow Transplant 1993 12: 21 25

    CAS  PubMed  Google Scholar 

  47. Beguin Y, Collignon J, Laurent C et al. Spontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome Br J Haematol 1996 94: 507 509

    CAS  PubMed  Google Scholar 

  48. Nemunaitis J, Singer JW, Buckner CD et al. Use of recombinant human granulocyte–macrophage colony-stimulating factor in graft failure after bone marrow transplantation Blood 1990 76: 245 253

    CAS  PubMed  Google Scholar 

  49. Sierra J, Terol MJ, Urbano-Ispizua A et al. Different response to recombinant human granulocyte–macrophage colony-stimulating factor in primary and secondary graft failure after bone marrow transplantation Exp Hematol 1994 22: 566 572

    CAS  PubMed  Google Scholar 

  50. Weisdorf DJ, Verfaillie CM, Davies SM et al. Hematopoietic growth factors for graft failure after bone marrow transplantation: a randomized trial of granulocyte–macrophage colony-stimulating factor (GM-CSF) versus sequential GM-CSF plus granulocyte-CSF Blood 1995 85: 3452 3456

    CAS  PubMed  Google Scholar 

  51. Zaucha JM, Gooley T, Bensinger WI et al. CD34 cell dose in granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cell grafts affects engraftment kinetics and development of extensive chronic graft versus-host disease after human leukocyte antigen-identical sibling transplantation Blood 2001 98: 3221 3227

    CAS  PubMed  Google Scholar 

  52. Aversa F, Tabilio A, Velardi A et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype New Engl J Med 1998 339: 1186 1193

    CAS  PubMed  Google Scholar 

  53. Asiedu C, Meng Y, Wang W et al. Immunoregulatory role of CD8alpha in the veto effect Transplantation 1999 67: 372 380

    CAS  PubMed  Google Scholar 

  54. Bergenthal A, Hofmann M, Heeg K . Self-veto mechanism of CD8+ cytotoxic effector T cells. Peptide-induced paralysis affects the peptide-MHC-recognizing cytotoxic T lymphocytes and is independent of Fas/Fas ligand interactions Eur J Immunol 1998 28: 1911 1922

    CAS  PubMed  Google Scholar 

  55. Gandy KL, Domen J, Aguila H et al. CD8+TCR+ and CD8+TCR− cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers Immunity 1999 11: 579 590

    CAS  PubMed  Google Scholar 

  56. Hirayama M, Genyea C, Brownell A et al. IL-2-activated murine newborn liver NK cells enhance engraftment of hematopoietic stem cells in MHC-mismatched recipients Bone Marrow Transplant 1998 21: 1245 1252

    CAS  PubMed  Google Scholar 

  57. Rachamim N, Gan J, Segall H et al. Tolerance induction by ‘megadose’ hematopoietic transplants: donor-type human CD34 stem cells induce potent specific reduction of host anti-donor cytotoxic T lymphocyte precursors in mixed lymphocyte culture Transplantation 1998 65: 1386 1393

    CAS  PubMed  Google Scholar 

  58. Raddatz G, Deiwick A, Sato T et al. Inhibition of cytotoxic alloreactivity by human allogeneic mononuclear cells: evidence for veto function of CD2+ cells Immunology 1998 94: 101 108

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Reisner Y, Martelli MF . Transplantation tolerance induced by ‘mega dose’ CD34+ cell transplants Exp Hematol 2000 28: 119 127

    CAS  PubMed  Google Scholar 

  60. Urbano-Ispizua A, Carreras E, Mann P et al. Allogeneic transplantation of CD34(+) selected cells from peripheral blood from human leukocyte antigen-identical siblings: detrimental effect of a high number of donor CD34(+) cells? Blood 2001 98: 2352 2357

    CAS  PubMed  Google Scholar 

  61. Guardiola P, Kuentz M, Garban F et al. Second early allogeneic stem cell transplantations for graft failure in acute leukaemia, chronic myeloid leukaemia and aplastic anaemia. French Society of Bone Marrow Transplantation Br J Haematol 2000 111: 292 302

    CAS  PubMed  Google Scholar 

  62. Remberger M, Ringden O, Liungman P et al. Booster marrow or blood cells for graft failure after allogeneic bone marrow transplantation Bone Marrow Transplant 1998 22: 73 78

    CAS  PubMed  Google Scholar 

  63. Grandage VL, Cornish JM, Pamphilon DH et al. Second allogeneic bone marrow transplants from unrelated donors for graft failure following initial unrelated donor bone marrow transplantation Bone Marrow Transplant 1998 21: 687 690

    CAS  PubMed  Google Scholar 

  64. Zecca M, Perotti C, Marradi P et al. Recombinant human G-CSF-mobilized peripheral blood stem cells for second allogeneic transplant after bone marrow graft rejection in children Br J Haematol 1996 92: 432 434

    CAS  PubMed  Google Scholar 

  65. Molina L, Chabannon C, Viret F et al. Granulocyte colony-stimulating factor-mobilized allogeneic peripheral blood stem cells for rescue graft failure after allogeneic bone marrow transplantation in two patients with acute myeloblastic leukemia in first complete remission Blood 1995 85: 1678 1679

    CAS  PubMed  Google Scholar 

  66. Selleri C, Raiola A, De Rosa G et al. CD34+ enriched donor lymphocyte infusions in a case of pure red cell aplasia and late graft failure after major ABO-incompatible bone marrow transplantation Bone Marrow Transplant 1998 22: 605 607

    CAS  PubMed  Google Scholar 

  67. Barrett AJ, Locatelli F, Treleaven JG et al. Second transplants for leukaemic relapse after bone marrow transplantation: high early mortality but favourable effect of chronic GVHD on continued remission. A report by the EBMT Leukaemia Working Party Br J Haematol 1991 79: 567 574

    CAS  PubMed  Google Scholar 

  68. Miniero R, Busca A, Vai S et al. Second bone marrow transplant for children who relapsed or rejected their first graft: experience of the Italian Pediatric Hematology and Oncology Group (AIEOP) Bone Marrow Transplant 1996 18 (Suppl 2): 135 138

    Google Scholar 

  69. Wagner JE, Vogelsang GB, Zehnbauer BA et al. Relapse of leukemia after bone marrow transplantation: effect of second myeloablative therapy Bone Marrow Transplant 1992 9: 205 209

    CAS  PubMed  Google Scholar 

  70. Kishi K, Takahashi S, Gondo H et al. Second allogeneic bone marrow transplantation for post-transplant leukemia relapse: results of a survey of 66 cases in 24 Japanese institutes Bone Marrow Transplant 1997 19: 461 466

    CAS  PubMed  Google Scholar 

  71. Tsai T, Goodman S, Saez R et al. Allogeneic bone marrow transplantation in patients who relapse after autologous transplantation Bone Marrow Transplant 1997 20: 859 863

    CAS  PubMed  Google Scholar 

  72. Aschan J, Remberger M, Carlens S et al. Unrelated donor stem cell transplantation after autologous transplantation: experience of a single center Bone Marrow Transplant 1999 24: 279 282

    CAS  PubMed  Google Scholar 

  73. Spinolo JA, Yau JC, Dicke KA et al. Second bone marrow transplants for relapsed leukemia Cancer 1992 69: 405 409

    CAS  PubMed  Google Scholar 

  74. Chiang KY, Weisdort DJ, Davies SM et al. Outcome of second bone marrow transplantation following a uniform conditioning regimen as therapy for malignant relapse Bone Marrow Transplant 1996 17: 39 42

    CAS  PubMed  Google Scholar 

  75. Lipton JH, Messner H . The role of second bone marrow transplant using a different donor for relapsed leukemia or graft failure Eur J Haematol 1997 58: 133 136

    CAS  PubMed  Google Scholar 

  76. Aoki Y, Takahashi S, Okamoto S et al. Graft-versus-leukemia after second allogeneic bone marrow transplantation Blood 1994 84: 3983

    CAS  PubMed  Google Scholar 

  77. Mattot M, Ninane J, Vermylen C et al. Second bone marrow transplantation in eight children Pediatr Hematol Oncol 1992 9: 353 357

    CAS  PubMed  Google Scholar 

  78. Mahon FX, Marit G, Viard F et al. Second bone marrow transplantation for leukemic relapse without graft-vs.-host disease prophylaxis Am J Hematol 1993 43: 324 325

    CAS  PubMed  Google Scholar 

  79. Martino R, Badell I, Brunet S et al. Second bone marrow transplantation for leukemia in untreated relapse Bone Marrow Transplant 1994 14: 589 593

    CAS  PubMed  Google Scholar 

  80. Mehta J, Powles R, Treleaven J et al. Outcome of acute leukemia relapsing after bone marrow transplantation: utility of second transplants and adoptive immunotherapy Bone Marrow Transplant 1997 19: 709 719

    CAS  PubMed  Google Scholar 

  81. Ashida T, Kawanishi K, Anyama T et al. Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia Int J Hematol 2000 71: 385 388

    CAS  PubMed  Google Scholar 

  82. Mrsic M, Horowitz MM, Atkinson K et al. Second HLA-identical sibling transplants for leukemia recurrence Bone Marrow Transplant 1992 9: 269 275

    CAS  PubMed  Google Scholar 

  83. Bosi A, Bacci S, Miniero R et al. Second allogeneic bone marrow transplantation in acute leukemia: a multicenter study from the Gruppo Italiano Trapianto Di Midollo Osseo (GITMO) Leukemia 1997 11: 420 424

    CAS  PubMed  Google Scholar 

  84. Michallet M, Tanguy ML, Socie G et al. Second allogeneic haematopoietic stem cell transplantation in relapsed acute and chronic leukaemias for patients who underwent a first allogeneic bone marrow transplantation: a survey of the Societe Francaise de Greffe de moelle (SFGM) Br J Haematol 2000 108: 400 407

    CAS  PubMed  Google Scholar 

  85. Radich JP, Sanders JE, Buckner CD et al. Second allogeneic marrow transplantation for patients with recurrent leukemia after initial transplant with total-body irradiation-containing regimens J Clin Oncol 1993 11: 304 313

    CAS  PubMed  Google Scholar 

  86. Ringden O, Labopin M, Frassoni F et al. Allogeneic bone marrow transplant or second autograft in patients with acute leukemia who relapse after an autograft. Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT) Bone Marrow Transplant 1999 24: 389 396

    CAS  PubMed  Google Scholar 

  87. Russell JA, Bowen T, Brown C et al. Second allogeneic transplants for leukemia using blood instead of bone marrow as a source of hemopoietic cells Bone Marrow Transplant 1996 18: 501 505

    CAS  PubMed  Google Scholar 

  88. Bensinger WI, Martin PJ, Store B et al. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers New Engl J Med 2001 344: 175 181

    CAS  PubMed  Google Scholar 

  89. Arslan O, Seferoglu A, Gurman G et al. Resistant graft failure overcome with allogenic peripheral blood plus bone marrow stem cells Haematologia 1998 29: 47 50

    CAS  PubMed  Google Scholar 

  90. Cobos E, Keung YK, Morgan D et al. Successful engraftment using allogeneic peripheral blood progenitor cells in a patient with primary bone marrow graft failure J Hematother 1995 4: 37 40

    CAS  PubMed  Google Scholar 

  91. Messori A, Bosi A, Bacci S et al. Retrospective survival analysis and cost-effectiveness evaluation of second allogeneic bone marrow transplantation in patients with acute leukemia. Gruppo Italiano Trapianto di Midollo Osseo Bone Marrow Transplant 1999 23: 489 495

    CAS  PubMed  Google Scholar 

  92. Or R, Mehta J, Kapelushnik J et al. Total lymphoid irradiation, anti-lymphocyte globulin and Campath 1-G for immunosuppression prior to bone marrow transplantation for aplastic anemia after repeated graft rejection Bone Marrow Transplant 1994 13: 97 99

    CAS  PubMed  Google Scholar 

  93. Herve P, Cahn JY, Flesch M et al. Successful graft-versus-host disease prevention without graft failure in 32 HLA-identical allogeneic bone marrow transplantations with marrow depleted of T cells by monoclonal antibodies and complement Blood 1987 69: 388 393

    CAS  PubMed  Google Scholar 

  94. Byrne JL, Stainer C, Cull G et al. The effect of the serotherapy regimen used and the marrow cell dose received on rejection, graft-versus-host disease and outcome following unrelated donor bone marrow transplantation for leukaemia Bone Marrow Transplant 2000 25: 411 417

    CAS  PubMed  Google Scholar 

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Wolff, S. Second hematopoietic stem cell transplantation for the treatment of graft failure, graft rejection or relapse after allogeneic transplantation. Bone Marrow Transplant 29, 545–552 (2002). https://doi.org/10.1038/sj.bmt.1703389

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