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Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report

Bone Marrow Transplantation volume 28, pages 1157–1160 (2001)Cite this article

Abstract

We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.

Bone Marrow Transplantation (2001) 28, 1157–1160.

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Acknowledgements

Mohamad Mohty was supported by a grant from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).

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Authors and Affiliations

  1. Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France

    M Mohty, B Gaugler, D Isnardon & D Olive

  2. Unité de Transplantation et de Thérapie Cellulaire (UTTC), Institut Paoli-Calmettes, Marseille, France

    M Mohty, C Faucher & D Blaise

  3. INSERM U119, Marseille, France

    B Gaugler & D Olive

  4. Département d'Hématologie, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France

    N Vey, D Sainty, C Arnoulet, MJ Mozziconacci, JA Gastaut, D Maraninchi & D Blaise

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  1. M Mohty
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  2. C Faucher
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  3. B Gaugler
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  4. N Vey
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  5. D Sainty
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  6. C Arnoulet
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  7. MJ Mozziconacci
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  8. D Isnardon
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  9. JA Gastaut
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  10. D Maraninchi
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  11. D Olive
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  12. D Blaise
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Mohty, M., Faucher, C., Gaugler, B. et al. Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report. Bone Marrow Transplant 28, 1157–1160 (2001). https://doi.org/10.1038/sj.bmt.1703308

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  • DOI: https://doi.org/10.1038/sj.bmt.1703308

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