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Post-Transplant Complications

Respiratory ciliary function in bone marrow recipients

Bone Marrow Transplantation volume 27, pages 1147–1151 (2001)Cite this article

Abstract

Bone marrow transplantation (BMT) recipients, particularly those with chronic graft-versus-host disease (GVHD), suffer from respiratory tract problems, including bronchiolitis obliterans (BO) and recurrent lower respiratory tract infections. Minute cilia beat continuously on the surface of respiratory mucosa, and this beating maintains the sterility of the lower respiratory tract. Dysfunction of respiratory cilia could lead to development of recurrent respiratory tract infections, which are also features of BMT recipients, although ciliary function has not been systematically studied among these subjects. We have, therefore, investigated the ciliary beat frequency (CBF) of 36 Chinese patients who had undergone allogeneic BMT. The CBF was significantly lower in the BMT group compared to controls (P < 0.001). The reduction in CBF was more severe in patients with cGVHD and BO compared with their counterparts (P = 0.048 and P = 0.077, respectively). There was a correlation between CBF with forced expiratory flow rate FEF (P = 0.024) and forced expiratory volume FEV (P = 0.044). We conclude that abnormal ciliary clearance is a common feature after allogeneic BMT, particularly among patients with BO and cGVHD. Further studies are indicated to evaluate this important phenomenon, which could be an important cause of the susceptibility for BMT recipients to respiratory infections. Bone Marrow Transplantation (2001) 27, 1147–1151.

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Acknowledgements

This study was supported by a Hong Kong RGC grant.

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Authors and Affiliations

  1. University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China

    WY Au, JC Ho, AK Lie, J Sun, L Zheng, R Liang, WK Lam & KW Tsang

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  1. WY Au
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  2. JC Ho
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  3. AK Lie
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Au, W., Ho, J., Lie, A. et al. Respiratory ciliary function in bone marrow recipients. Bone Marrow Transplant 27, 1147–1151 (2001). https://doi.org/10.1038/sj.bmt.1703049

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