Abstract
LET it be assumed that: (a) each organism invading a host has a chance λ of reaching a favourable site, and of afterwards undergoing a sequence of events which enable it to proliferate and result in the death (or infection) of the host; (b) each organism acts independently; (c) c inhaled organisms are necessary to produce the death (or infection) of 0.5 of the total of exposed animals; (d) the experimental animal population is large and homogeneous. Then the proportion S of animals remaining uninfected after the intake of n organisms each is given by: S = (1 — λ)n, and by definition 0.5 = (1 — λ)c, Expressing n in units of c that is, n = fc, S = (1 — λ)fc = 0.5f.
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Druett, H. A., Henderson, D. W., Packman, L., and Peacock, S. V. (in preparation).
Elberg, S. S., and Henderson, D. W., J. Inf. Dis., 82, 302 (1948).
Goldberg, L. J., and Watkins, H. M. S., Bact. Proc., Soc. Am. Bact., 74 (1952).
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DRUETT, H. Bacterial Invasion. Nature 170, 288 (1952). https://doi.org/10.1038/170288a0
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DOI: https://doi.org/10.1038/170288a0
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