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Successful haploidentical bone marrow transplantation in Fanconi anemia

Bone Marrow Transplantation volume 26, pages 1221–1223 (2000)Cite this article

Abstract

A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available. Bone Marrow Transplantation (2000) 26, 1221–1223.

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Authors and Affiliations

  1. Department of Pediatric Hemato-Oncology, Rambam Medical Center and Technion, Haifa, Israel

    R Elhasid, MWeyl Ben Arush & S Postovsky

  2. Department of Hematology, Rambam Medical Center and Technion, Haifa, Israel

    T Katz, Y Shechter & JM Rowe

  3. Department of Immunology, Rambam Medical Center and Technion, Haifa, Israel

    Y Gan & I Sami

  4. Department of Immunology, Weizmann Institute, Rehovot, Israel

    Y Reisner

Authors
  1. R Elhasid
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  2. MWeyl Ben Arush
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  3. T Katz
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  4. Y Gan
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  5. Y Shechter
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  6. I Sami
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  7. S Postovsky
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  8. Y Reisner
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  9. JM Rowe
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Elhasid, R., Ben Arush, M., Katz, T. et al. Successful haploidentical bone marrow transplantation in Fanconi anemia. Bone Marrow Transplant 26, 1221–1223 (2000). https://doi.org/10.1038/sj.bmt.1702701

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  • DOI: https://doi.org/10.1038/sj.bmt.1702701

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