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Myeloma

Donor leukocyte infusions for multiple myeloma

Bone Marrow Transplantation volume 26, pages 1179–1184 (2000)Cite this article

Abstract

Donor leukocyte infusion (dli) has well-documented activity in cml, but the role of dli in other diseases is less well defined. to evaluate the strategy in multiple myeloma (mm) we evaluated 25 mm patients from 15 centers who were treated with dli. patients with persistent or recurrent disease after allogeneic bmt received dli from the original marrow donor (23 matched related, one mismatched family, and one matched unrelated). chemotherapy was given before dli in three patients. two of 22 patients responded completely to dli alone and three patients responded to the combination of dli and chemotherapy. nine patients who had not had sufficient disease control after dli were given additional dlis; five of these patients had either complete (two) or partial (three) responses. thirteen of 25 evaluable patients developed acute gvhd and 11 of 21 evaluable patients developed chronic gvhd; all responders developed gvhd. no patients developed post-dli pancytopenia. four patients had responses which lasted >1 year after DLI, three patients had responses which lasted <1 year, and three patients had ongoing responses but with follow-up <1 year. In conclusion, DLI has anti-myeloma activity but the strategy is limited by no response or short duration of response in a significant percentage of patients and by significant GVHD in the majority of the responders. Bone Marrow Transplantation (2000) 26, 1179–1184.

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Acknowledgements

We thank Shanna Morris for data management, Jane Pryor for assistance in manuscript preparation and the Leukemia Association of North Central Texas for financial support.

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Authors and Affiliations

  1. University of Texas Southwestern Medical Center, Dallas, Texas, USA

    M Salama & RH Collins

  2. Vancouver Hospital and Health Sciences Center, Vancouver, British Columbia, Canada

    T Nevill

  3. Johns Hopkins University Hospital, Baltimore, Maryland, USA

    D Marcellus

  4. City of Hope, Duarte, California, USA

    P Parker

  5. Baylor-Sammons Cancer Center, Dallas, Texas, USA

    M Johnson, A Kirk & RH Collins

  6. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    D Porter

  7. MD Anderson Cancer Center, Houston, Texas, USA

    S Giralt

  8. University of Michigan, Ann Arbor, Michigan, USA

    JE Levine

  9. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    W Drobyski & M Horowitz

  10. National Heart Lung and Blood Institute, Bethesda, Maryland, USA

    AJ Barrett

  11. International Bone Marrow Transplant Registry, Milwaukee, Wisconsin, USA

    M Horowitz

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  1. M Salama
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Appendix: study participants

Appendix: study participants

The following transplant centers contributed to this study by reporting patients: Baylor, Dallas: R Collins (n = 6); Vancouver General Hospital: T Nevill (n = 3); Johns Hopkins University: D Marcellus (n = 3); City of Hope: P Parker (n = 2); Arizona Cancer Center: A Briggs (n = 1); LDS Hospital: C Ford (n = 1); MD Anderson Cancer Center: S Giralt (n = 1); UCSF: C Linker (n = 1); Hospital de Sant Pau, Barcelona: R Martino (n = 1); Christchurch Hospital, New Zealand: N Patton (n = 1); Ohio State University: S Penza (n = 1); St Louis University: S Pincus (n = 1); University of Rochester: A Rapoport (n = 1); UCLA: M Territo (n = 1); Rocky Mountain Cancer Center: R Rifkin (n = 1)

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Salama, M., Nevill, T., Marcellus, D. et al. Donor leukocyte infusions for multiple myeloma. Bone Marrow Transplant 26, 1179–1184 (2000). https://doi.org/10.1038/sj.bmt.1702685

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