Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Successful treatment of relapsed Burkitt's lymphoma using unrelated cord blood transplantation as consolidation therapy

Bone Marrow Transplantation volume 25, pages 1311–1313 (2000)Cite this article

Abstract

We report a 10-year-old male with widespread recurrent Burkitt's lymphoma who underwent successful mismatched unrelated cord blood transplantation (UCBT) following salvage chemotherapy. He was conditioned with TBI, antithymocyte globulin (ATG) and high-dose VP-16 and achieved full donor engraftment. He experienced grade II skin and grade I gastrointestinal acute GVHD with no chronic GVHD. He is alive with no evidence of disease 24 months following UCBT. Bone Marrow Transplantation (2000) 25, 1311–1313.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Shad A, Magrath I . Malignant non-Hodgkin's lymphomas in children. In: Pizzo PA, Poplack DG (eds) Principles and Practice of Pediatric Oncology Lippincott-Raven: Philadelphia 1997 545–587

    Google Scholar 

  2. Ladenstein R, Pearce R, Hartmann O et al. High-dose chemotherapy with autologous bone marrow rescue in children with poor-risk Burkitt's lymphoma: a report from the European Lymphoma Bone Marrow Transplantation Registry Blood 1997 90: 2921–2930

    CAS  PubMed  Google Scholar 

  3. Jones RJ, Ambinder RF, Piantadosi S, Santos GW . Evidence of a graft-versus-lymphoma effect associated with allogeneic bone marrow transplantation Blood 1991 77: 649–653

    CAS  Google Scholar 

  4. Lundberg JH, Hansen RM, Chitambar CR et al. Allogeneic bone marrow transplantation for relapsed and refractory lymphoma using genotypically HLA-identical and alternative donors J Clin Oncol 1991 9: 1848–1859

    Article  CAS  Google Scholar 

  5. Bureo E, Ortega JJ, Muñoz A et al. Bone marrow transplantation in 46 pediatric patients with non-Hodgkin's lymphoma Bone Marrow Transplant 1995 3: 353–359

    Google Scholar 

  6. Ratanatharathorn V, Uberti J, Karanes C et al. Prospective comparative trial of autologous versus allogeneic bone marrow transplantation in patients with non-Hodgkin's lymphoma Blood 1994 84: 1050–1055

    CAS  Google Scholar 

  7. Gluckman E, Rocha V, Boyer-Chammard A et al. Outcome of cord-blood transplantation from related and unrelated donors New Engl J Med 1997 337: 373–381

    Article  CAS  Google Scholar 

  8. Rubinstein P, Carrier C, Scaradavou A et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors New Engl J Med 1998 339: 1565–1577

    Article  CAS  Google Scholar 

  9. Harris DT . In vitro and in vivo assessment of the graft-versus-leukemia activity of cord blood Bone Marrow Transplant 1995 15: 17–23

    CAS  PubMed  Google Scholar 

  10. Wagner JE, Rosenthal J, Sweetman R et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease Blood 1996 88: 795–802

    CAS  Google Scholar 

  11. Goldman SG, Munoz L, Lenarsky C, Weinthal J . TBI/VP-16 with ATG is sufficient for sustained engraftment following mismatched unrelated cord blood transplantation in children with high risk leukemia and lymphoma. Presented at the Fifth Annual Marrow Transplantation in Children Conference, Hilton Head, South Carolina, February 2000

Download references

Author information

Authors and Affiliations

  1. Texas Oncology Pediatrics and North Texas Hospital for Children at Medical City Dallas Hospital, Dallas, TX, USA

    JA Weinthal, SC Goldman & C Lenarsky

Authors
  1. JA Weinthal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. SC Goldman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C Lenarsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weinthal, J., Goldman, S. & Lenarsky, C. Successful treatment of relapsed Burkitt's lymphoma using unrelated cord blood transplantation as consolidation therapy. Bone Marrow Transplant 25, 1311–1313 (2000). https://doi.org/10.1038/sj.bmt.1702428

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702428

Keywords

Search

Advanced search

Quick links